Abstract
Ninety-eight patients with common varied immunodeficiency have been observed for periods of 1–13 years. In 1986, 78 were alive, 19 had died, and 1 could not be located. Eleven patients in the group had developed cancer; two patients had had two cancers. Of the total number of neoplastic malignancies, seven were non-Hodgkin's lymphoma, one patient had a Waldenstrom's macroglobulinemia, and nine of the patients who developed cancer were female. Cancer developed in the fifth or sixth decade of life for 10 of the 11 patients. These data show an 8- to 13-fold increase in cancer in general for patients who have this immunodeficiency and a 438-fold increase in lymphoma for females.
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Since the submission of this report, an additional female patient, aged 55 years, has developed Stage I, nodular lymphoma in the parotid gland.
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Cunningham-Rundles, C., Siegal, F.P., Cunningham-Rundles, S. et al. Incidence of cancer in 98 patients with common varied immunodeficiency. J Clin Immunol 7, 294–299 (1987). https://doi.org/10.1007/BF00915550
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DOI: https://doi.org/10.1007/BF00915550