Abstract
Three cases of symptomatic neuralgia of the trigeminal nerve due to an amyloidoma in the gasserian ganglion are described. The correct diagnosis was not made prior to histological examination of the surgical biopsy specimens. Medical history and clinical observation led to the diagnosis of a malignant process of the nasal cavities in the first patient; of an inflammatory dental focus in the second patient; and of multiple sclerosis in the third patient. CT findings were normal in cases 1 and 2; in case 3, a schwannoma was suspected from the CT appearances. In case 1, MRI had not been performed; in cases 2 and 3, MRI revealed a tumour mass which was also considered to be a schwannoma. Histologically, the tumours consisted of masses of amyloid deposits which had largely replaced the pre-existing ganglionic cells and satellite cells. Electron microscopy confirmed the fibrillar structure of the deposits. Immunohistochemistry and immunocytochemistry revealed the amyloid to belong to the AL-lambda subtype.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Borghi G, Tagliabue G (1961) Primary amyloidosis of the gasserian ganglion. Acta Neurol Scand 37:105–110
Cohen AS, Connors LH (1987) The pathogenesis and biochemistry of amyloidosis. J Pathol 151:1–10
Daly DD, Grafton Love J, Dockerty MB (1957) Amyloid tumor of the gasserian ganglion. J Neurosurg 14:347–352
DeCastro S, Sparks JT, Lapey JD, Freidberg SR (1976) Amyloidoma of the gasserian ganglion. Surg Neurol 6:357–359
Ferreiro JA, Bhuta S, Nieberg RK, Verity A (1990) Amyloidoma of the skull base. Arch Pathol Lab Med 114:974–976
Glenner GG (1980) Amyloid deposits and amyloidosis. The β-fibrilloses. N Engl J Med 302:1283–1292; 1333–1343
Glenner GG, Terry W, Harada M, et al (1971) Amyloid fibril proteins: proof of homology with immunoglobulin light chains by sequence analyses. Science 172:1150–1151
Husby G, Araki S, Benditt EP, Benson MD, Cohen AS, Frangione B, Glenner GG, Natvig JB, Westermark P (1991) The 1990 guidelines for nomenclature and classification of amyloid and amyloidoses. In: Natvig JB, et al (eds) Amyloid and amyloidoses 1990. VIth International Symposium on Amyloidosis, 5–8 August 1990, Oslo, Norway. Kluwer, Dordrecht, pp 7–11
Kyle RA (1991) Primary systemic amyloidosis (AL) in 1990. In: Natvig JB, et al (eds) Amyloid and amyloidoses 1990. VIth International Symposium on Amyloidosis, 5–8 August 1990, Oslo, Norway. Kluwer, Dordrecht, pp 147–152
Linke RP, Nathrath WBJ, Eulitz M (1986) Classification of amyloid syndromes from tissue sections using antibodies against various amyloid fibril proteins: report of 142 cases. In: Glenner GG, et al (eds) Amyloidosis. Plenum, New York, pp 599–605
Matsumoto T, Tani E, Maeda Y, Natsuma S (1985) Amyloidomas in the cerebellopontine angle and jugular foramen. J Neurosurg 62:592–596
Wright JR, Calkins E, Humphrey RL (1977) Potassium permanganate reaction in amyloidosis. Lab Invest 36:274–281
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bornemann, A., Bohl, J., Goebel, H.H. et al. Amyloidoma of the gasserian ganglion as a cause of symptomatic neuralgia of the trigeminal nerve: Report of three cases. J Neurol 241, 10–14 (1993). https://doi.org/10.1007/BF00870665
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00870665