Abstract
A 14-year-old boy who had had a splenectomy at the age of 2 years for idiopathic thrombocytopenic purpura, suffered from IgA nephropathy. Serum IgA and IgE levels were elevated and low levels of circulating immune complexes were detected. Splenectomy may play a role in the pathogenesis or susceptibility to IgA nephropathy by means of decreased clearance of circulating immune complexes or impaired immune regulation, such as increased IgA synthesis.
Article PDF
Avoid common mistakes on your manuscript.
References
Watanabe K, Watanabe H, Kida S, Funabasi Y, Ookubo Y, et al (1989) Detection of immune complexes by monoclonal anti-C1q and C3d ELISA systems. Jpn J Clin Immunol 12:369–378
van den Wall Bake AWL, Daha MR, Haaijman JJ, Radl J, van der Ark A, van Es LA (1989) Elevated production of polymeric and monomeric IgA1 by the bone marrow in IgA nephropathy. Kidney Int 35:1400–1404
van Es LA (1992) Pathogenesis of IgA nephropathy. Kidney Int 41:1720–1729
Smith SM, Tokuda S, Tsukamoto H (1992) Mucosal immune dysfunction associated with alcoholic IgA nephropathy. Clin Immunol Immunopathol 64:205–209
Drew PA, Kiroff GK, Ferrante A, Cohen RC (1984) Alterations in immunoglobulin sysnthesis by peripheral blood mononuclear cells from splenectomized patients with and without splenic regrowth. J Immunol 132:191–196
Emancipator SN, Lamm ME (1989) Biology of disease. IgA nephropathy: pathogenesis of the most common form of glomerulonephritis. Lab Invest 60:168–183
Haakenstad AO, Mannik M (1976) The disappearance kinetics of soluble immune complexes prepared with reduced and alkylated antibodies and with intact antibodies in mice. Lab Invest 35: 283–292
Roccatello D, Piccitto G, Coppo R, Piccoli G, Molino A, Cacace G, Amore A, Quattrocchio G, Ropolo R, Mossso R, Amoroso A, Sena LM (1991) The fate of aggregated immunoglobulin A injected in IgA nephropathy patients and healthy controls. Am J Kidney Dis 18:20–25
Lobatto S, Daha MR, Voetman AA, Evers-schouten JH, van Es AA, Pauels EKJ, van Es LA (1987) Clearance of soluble aggregates of human immunoglobulin G in healthy volunteers and chimpanzees. Clin Exp Immunol 68:133–141
Emancipator SN, Lamm ME (1989) IgA nephropathy: over-production or decreased clearance of immune complexes?, Lab Invest 61:365–367
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Morino, M., Inami, K., Shibuya, A. et al. IgA nephropathy and idiopathic thrombocytopenic purpura with splenectomy: a case report. Pediatr Nephrol 8, 345–346 (1994). https://doi.org/10.1007/BF00866358
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00866358