Abstract
Between 1970 and 1984, the diagnosis of glomerulonephritis was made in 860 patients on the basis of a nephritic sediment and/or renal biopsy; of these patients, 86 (10%) had at least one first-degree relative with glomerulonephritis. These patients originated from 45 families and 1674 family members were screened; 172 had glomerulonephritis, of whom 101 could be classified. The diagnostic breakdown of the 101 patients showed that 50.5% had classical Alport's syndrome; 21.8% had atypical forms; 17.8% had familial IgA glomerulonephritis; 1.9% had focal segmental glomerulosclerosis with Wolff-Parkinson-White syndrome; and 7.9% had benign familial haematuria. The proportion of patients with glomerulonephritis who had familial disease was higher than expecte. The family history is an important point to consider in the examination of patients with glomerulonephritis.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Dickinson WH (1875) Diseases of the kidney and urinary derangements, part 2. Longmans Green, London, p 378
Guthrie LB (1902) Idiopathic or congenital hereditary and family haematuria. Lancet I: 1243–1246
Alport AC (1927) Hereditary familial congenital hemorrhagic nephritis. Br Med J I: 504–506
Waldherr R (1982) Familial glomerular disease. Contrib Nephrol 33: 104–121
Grünfeld JP (1985) The clinical spectrum of hereditary nephritis. Kidney Int 27: 83–92
Tina L, Jenis E, Jose P, Medani C, Papadopoulos Z, Calcagno P (1982) The glomerular basement membrane in benign familial hematuria. Clin Nephrol 17: 1–4
Gubler MC, Lévy M, Broyer M, Naizot C, Gonzales G, Perrin D, Habib R (1981) Alport's syndrome—a report of 58 cases and a review of the literature. Am J Med 70: 493–505
Habib R, Gubler MC, Hinglais N, Noël LH, Droz D, Lévy M, Mahieu P, Foidart JM, Perrin D, Bois E, Grünfeld JP (1982) Alport's syndrome: experience at Hôpital Necker. Kidney Int 21: S20-S28
Yoshikawa N, White RHR, Cameron AH (1982) Familial hematuria: clinico-pathological correlations. Clin Nephrol 17: 172–182
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Rambausek, M., Hartz, G., Waldherr, R. et al. Familial glomerulonephritis. Pediatr Nephrol 1, 416–418 (1987). https://doi.org/10.1007/BF00849246
Issue Date:
DOI: https://doi.org/10.1007/BF00849246