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Abbreviations
- 8-OHG:
-
8-hydroxy-2′-deoxyguanosine
- CAT:
-
catalase
- DEM:
-
dimethyl maleate
- DMSO:
-
dimethyl sulfoxide
- G6PD:
-
glucose-6-phosphate dehydrogenase
- GlyGlyHis:
-
glycylglycyl-L-histidine
- GPx:
-
glutathione peroxidase
- GSH:
-
reduced glutathione
- GST:
-
GSHS-transferase
- MT:
-
metallothionein
- SOD:
-
superoxide dismutase
- V79:
-
Chinese hamster V79 cells
References
Antioxidants
Floyd RA. The role of 8-hydroxyguanine in carcinogenesis. Carcinogenesis 1990;11:1447–50.
Hochstein P, Atallah AS. The nature of antioxidant systems in the inhibition of mutation and cancer. Mutat Res. 1988;202:363–75.
Meneghini R. Genotoxicity of active oxygen species in mammalian cells. Mutat Res. 1988;195:215–30.
Sun Y Free radicals, antioxidant enzymes, and carcinogenesis. Free Rad Biol Med. 1990;8:583–99.
Chromium
Aiyar J, Berkovits HJ, Floyd RA, Wetterhahn KE. Reaction of chromium(VI) with hydrogen peroxide in the presence of glutathione: reactive intermediates and resulting DNA damage. Chem Res Toxicol 1990;3:595–603.
Capellmann M, Bolt HM. Chromium(VI) reducing capacity of ascorbic acid and of human plasmain vitro. Arch Toxicol. 1992;66:45–50.
De Flora S, Wetterhahn KE. Mechanism of chromium(VI) metabolism and genotoxicity. Life Chem Rep. 1989;7: 169–244.
De Flora S, Bagnasco M, Serra D, Zanacchi P. Genotoxicity of chromium compounds: a review. Mutat Res. 1990;238: 99–172.
Faux SP, Gao M, Chipman JK, Levy LS. Production of 8-hydroxydeoxyguanosine in isolated DNA by chromium(VI) and chromium(V). Carcinogenesis. 1992;13:1667–9.
Kawanishi S, Inoue S, Sano S Mechanism of DNA cleavage-induced by sodium chromate(VI) in the presence of hydrogen peroxide. J Biol Chem. 1986;261:5952–8.
Koutras GA, Hattori J, Schneider AS, Ebaugh FGJ, Valentine WN. Studies on chromated erythrocytes: effect of sodium chromate on erythrocyte glutathione reductase. J Clin Invest. 1964;43:323–31.
Lefebvre Y, Pézerat H. Production of activated species of oxygen during the chromate(VI)-ascorbate reaction: Implication in carcinogenesis. Chem Res Toxicol. 1992;5:461–3.
Ozawa T, Hanaki A. Spin-trapping studies on the reactions of Cr(III) with hydrogen peroxide in the presence of biological reductants: Is Cr(III) non-toxic? Biochem Int. 1990;22:343–52.
Salnikow K, Zhitkovich A, Costa M. Analysis of the binding sites of chromium to DNA and proteinin vitro and in intact cells. Carcinogenesis. 1992;13:2341–6.
Sengupta T, Chattopadhyay D, Ghosh N, Das M, Chatterjee GC. Effect of chromium administration on glutathione cycle of rat intestinal epithelial cells. Indian J Exp Biol. 1990;28:1132–5.
Shi X, Dalal NS. On the hydroxyl radical formation in the reaction between hydrogen peroxide and biologically generated chromium(V) species. Arch Biochem Biophys. 1990;277:342–50.
Shi X, Dalal NS. The role of superoxide radical in chromium(VI)-generated hydroxyl radical: the Cr(VI) Haber-Weiss cycle. Arch Biochem Biophys. 1992; 292:323–7.
Shi X, Sun X, Gannett PM, Dalal NS. Deferoxamine inhibition of Cr(V)-mediated radical generation and deoxyguanine hydroxylation: ESR and HPLC evidence. Arch Biochem Biophys. 1992;293:281–6.
Shi X, Dalal NS, Kasprzak KS. Generation of free radicals from hydrogen peroxide and lipid hydroperoxides in the presence of Cr(III). Arch Biochem Biophys. 1993;302:294–9.
Standeven AM, Wetterhahn KE. Is there a role for reactive oxygen species in the mechanism of chromium(VI) carcinogenesis? Chem Res Toxicol. 1991;4:616–25.
Standeven AM, Wetterhahn KE. Ascorbate is the principal reductant of chromium(VI) in rat lung ultrafiltrates and cytosols, and mediates chromium-DNA bindingin vitro. Carcinogenesis. 1992;13:1319–24.
Sugden KD, Geer RD, Rogers SJ. Oxygen radical-mediated DNA damage by redox-active Cr(III) complexes. Biochemistry. 1992;31:11626–31.
Sugiyama M. Role of physiological antioxidants in chromium(VI)-induced cellular injury. Free Rad Biol Med. 1992;12:397–407.
Sugiyama M, Ando A, Nakao K, Ueta H, Hidaka T, Ogura R. Influence of vitamin B2 on formation of chromium(V), alkali-labile sites, and lethality of sodium chromate(VI) in Chinese hamster V-79 cells. Cancer Res 1989;49:6180–4.
Sugiyama M, Tsuzuki K, Ogura R. Effect of ascorbic acid on DNA damage, cytotoxicity, glutathione reductase, and formation of paramagnetic chromium in Chinese hamster V-79 cells treated with sodium chromate(VI). J Biol Chem. 1991;266:3383–6.
Sugiyama M, Tsuzuki K, Haramaki N. DNA single-strand breaks and cytotoxicity induced by chromate(VI) in hydrogen peroxide-resistant cell lines. Mutat Res. 1993a;299:95–102.
Sugiyama M, Tsuzuki K, Haramaki N. Influence ofo-phenanthroline on DNA single strand breaks, alkali-labile sites, glutathione reductase, and formation of chromium(V) in Chinese hamster V-79 cells treated with sodium chromate(VI). Arch Biochem Biophys. 1993b;305:261–6.
Wise JP, Orenstein JM, Patierno SR. Inhibition of lead chromate clastogenesis by ascorbate: relationship to particle dissolution and uptake. Carcinogenesis. 1993;14:429–34.
Nickel
Andersen HR, Andersen O. Effect of nickel chloride on hepatic lipid peroxidation and glutathione concentration in mice. Biol Trace Elem Res. 1989;21:255–61.
Arrouijal FZ, Hildebrand HF, Vophi H, Marzin D. Genotoxic activity of nickel subsulfide α-Ni3S2. Mutagenesis. 1990;6:583–9.
Arsalane K, Aerts C, Wallaert B, Voisin C, Hildebrand HF. Effects of nickel hydroxycarbonate on alveolar macrophage functions. J Appl Toxicol. 1992;12:285–90.
Athar M, Hasan SK, Srivastava R. Evidence for the involvement of hydroxyl radicals in nickel mediated enhancement of lipid peroxidation: Implications for nickel carcinogenesis. Biochem Biophys Res Commun. 1987;147:1276–81.
Cartana J, Romeu A, Arola L. Effects of copper, cadmium and nickel on liver and kidney glutathione redox cycle of rats (Rattus sp.). Comp Biochem Physiol. [C] 1992;101:209–13.
Chang J, Watson WP, Randerath E, Bulky DNA-adduct formation induced by Ni(II)in vitro andin vivo as assayed by32P-postlabeling. Mutat Res. 1993;291:147–59.
Christie NT, Katsifis SP. Nickel carcinogenesis. In: Foulkes EC, ed. Biological effects of heavy metals, vol. II, Metal carcinogenesis. Baton Rouge, FL: CRC Press 1990:95–128.
Christie NT, Tummolo DM, Klein CB, Rossman TG. The role of Ni(II) in mutation. In: Nieboer E, Nriagu J eds. Nickel and human health: current perspectives. New York: Wiley; 1992:305–17 (Advances in environmental science and technology; vol.25).
Coogan TP, Latta DM, Snow ET, Costa M. Toxicity and carcinogenicity of nickel compounds. CRC Crit Rev Toxicol. 1989;19:341–84.
Costa M. Molecular mechanisms of nickel carcinogenesis. Annu Rev Pharmacol Toxicol. 1991;31:321–37.
Cotelle N, Tremolieres E, Bernier JL, Catteau JP, Henichart JP. Redox chemistry of complexes of nickel(II) with some biologically important peptides in the presence of reduced oxygen species: an ESR study. J Inorg Biochem. 1992;46:7–15.
Inoue S, Kawanishi S. ESR evidence for superoxide, hydroxyl radicals and singlet oxygen produced from hydrogen peroxide and nickel(II) complex of glycylglycyl-L-histidine. Biochem Biophys Res Commun. 1989;159:445–51.
Iscan M, Coban T, Eke BC. Responses of hepatic xenobiotic metabolizing enzymes of mouse, rat and guinea-pig to nickel. Pharmacol Toxicol. 1992;71:434–42.
Kargacin B, Klein CB, Costa M. Mutagenic responses of nickel oxides and nickel sulfides in Chinese hamster V79 cell lines at the xanthine-guanine phosphoribosyl transferase locus. Mutat Res. 1993;300:63–72.
Kasprzak KS. The role of oxidative damage in metal carcinogenicity. Chem Res Toxicol. 1991;4:604–15.
Kasprzak KS, Hernandez L. Enhancement of hydroxylation and deglycosylation of 2′-deoxyguanosine by carcinogenic nickel compounds. Cancer Res. 1989;49:5964–8.
Kawanishi S, Inoue S, Yamamoto K. Site-specific DNA damage induced by nickel(II) ion in the presence of hydrogen peroxide. Carcinogenesis. 1989;10:2231–5.
Klein CB, Frankel K, Costa M. The role of oxidative processes in metal carcinogenesis. Chem Res Toxicol. 1991;4:592–603.
Li W, Zhao Y, Chou IN. Alterations in cytoskeletal protein sulfhydryls and cellular glutathione in cultured cells exposed to cadmium and nickel ions. Toxicology. 1993;77:65–79.
Lin XH, Sugiyama M, Costa M. Differences in the effect of vitamin E on nickel sulfide or nickel chloride-induced chromosomal aberrations in mammalian cells. Mutat Res. 1991;260:159–64.
Misra N, Rodriguez RE, Kasprzak, KS. Nickel induced lipid peroxidation in the rat: correlation with nickel effect on antioxidant defense systems. Toxicology. 1990;64:1–17.
Misra M, Rodriguez RE, North SL, Kasprazak KS. Nickel-induced renal lipid peroxidation in different strains of mice: concurrence with nickel effect on antioxidant defense systems. Toxicol Lett. 1991;58:121–33.
Miyaki M, Akamatsu N, Ono T, Koyama H. Mutagenicity of metal cations in cultured cells from Chinese hamsters. Mutat Res. 1979;68:259–63.
Nackerdien Z, Kasprzak KS, Rao G, Halliwell B, Dizdaroglu M. nickel(II)- and cobalt(II)-dependent damage by hydrogen peroxide to the DNA bases in isolated human chromatin. Cancer Res. 1991;51:5837–42.
Nieboer E, Maxwell RI, Stafford AR. Chemical and biological reactivity of insoluble nickel compounds and the bioinorganic chemistry of nickel. In: Sunderman FW, ed. Nickel and the human environment. Lyon, France: IARC; 1984;439–58. (IARC scientific publications; vol. 53).
Nieboer E, Tom RT, Rossetto FE. Superoxide dismutase activity and novel reactions with hydrogen peroxide of histidine-containing nickel(II)-oligopeptide complexes and nickel(II)-induced structural changes in synthetic DNA. Biol Trace Elem Res. 1989;21:23–33.
Novelli EL, Sforcin JM, Rodrigues NL, Ribas BO. Pancreas damage and intratracheal NiCl2 administration. Effects of nickel chloride. Bol Estud Med Biol. 1990;38:54–8.
Novelli EL, Rodrigues NL, Ribas BO, Curi PR. Intratracheal injection of nickel chloride and copper-zinc superoxide dismutase activity in lung of rats. Can J Physiol Pharmacol. 1992;70:709–11.
Rodriguez RE, Misra M, Kasprzak KS. Effects of nickel on catalase activityin vitro andin vivo. Toxicology. 1990;63:45–52.
Rodriguez RE, Misra M, North SL, Kasprzak KS. Nickel-induced lipid peroxidation in the liver of different strains of mice and its relation to nickel effects on antioxidant systems. Toxicol Lett. 1991;57:269–81.
Shi X, Dalal NS, Kasprzak KS. Generation of free radicals from lipid hydroperoxides by Ni2+ in the presence of oligopeptides. Arch Biochem Biophys. 1992;299:154–62.
Srivastava RC, Kumar A, Srivastava SK, Gupta S, Hasan SK, Athar M. Nickel-mediated inhibition in the glutathione-dependent protection against lipid peroxidation. Biochem Int. 1990;20:495–501.
Sunderman FW Jr. Carcinogenicity of nickel compounds in animals. In: Sunderman FW, ed. Nickel and the human environment. Lyon, France: IARC; 1984;127–42. (IARC scientific publications, vol. 53).
Sunderman FW, Hopfer SM, Knight JA et al. Physicochemical characteristics and biological effects of nickel oxides. Carcinogenesis. 1987;8:305–13.
Zhong Z, Troll W, Koenig KL, Frenkel K. Carcinogenic sulfide salts of nickel and cadmium induce H2O2 formation by human polymorphonuclear leukocytes. Cancer Res. 1990;50:7564–70.
Cadmium
Abel J, de Ruiter N. Inhibition of hydroxyl radical-generated DNA degradation by metallothionein. Toxicol Lett. 1989;47:101–7.
Almar MM, Dierickx PJ. In vitro interaction of mercury, copper(II) and cadmium with human glutathione transferase pi. Res Commun Chen Pathol Pharmacol. 1990;69:99–102.
Amoruso MA, Witz G, Goldstein BD. Enhancement of rat and human phagocyte superoxide anion radical production by cadmiumin vitro. Toxicol Lett. 1982;10:133–8.
Angle CR, Thomas DJ, Swanson SA. Toxicity of cadmium to rat osteosarcoma cells (ROS 17/2.8): protective effect of 1α,25-dihydroxyvitamin D3. Toxicol Appl Pharmacol. 1990;103:113–20.
Bannai S, Sato H, Ishii T, Taketani S. Enhancement of glutathione levels in mouse, peritoneal macrophages by sodium arsenite, cadmium chloride and glucose/glucose oxidase. Biochim Biophys Acta. 1991;1092:175–9.
Bauman JW, McKim JMJ, Liu J, Klaassen CD. Induction of metallothionein by diethyl maleate. Toxicol Appl Pharmacol. 1992;114:188–96.
Beach LR, Palmiter RD. Amplification of the metallothionein-I gene in cadmium-resistant mouse cells. Proc Natl Acad Sci USA. 1981;78:2110–4.
Beach LR, Mayol KE, Durnam DM, Palmiter RD. Metallothionein-I gene in cadmium-resistant mouse cell lines. In: Brown DD, Fox CF, eds. Developmental biology using purified genes. New York: Academic Press (ICN-UCLA symposia on molecular and cellular biology, vol. XXIII); 1981.
Bell RR, Nonavinakere VK, Soliman MR, Early JL. Effect ofin vitro treatment of rat hepatocytes with selenium, and/or cadmium on cell viability, glucose output, and cellular glutathione. Toxicology. 1991;69:111–9.
Bjerrum MJ, Bauer R, Danielsen E, Kofod P. The Zn-site in bovine copper, zinc superoxide dismutase studied by111Cd PAC. Free Radic Res Commun. 1991;12–13:297–303.
Chan HM, Cherian MG. Protective roles of metallothionein and glutathione in hepatotoxicity of cadmium. Toxicology. 1992;72:281–90.
Chin TA, Templeton DM. Protective elevations of glutathione and metallothionein in cadmium-exposed mesangial cells. Toxicology. 1993;77:145–56.
Chubatsu LS, Gennari M, Meneghini R. Glutathione is the antioxidant responsible for resistance to oxidative stress in V79 Chinese hamster fibroblasts rendered resistant to cadmium. Chem Biol Interact. 1992;82:99–110.
Coogan TP, Bare RM, Waalkes MP. Cadmium-induced DNA strand damage in cultured liver cells: reduction in cadmium genotoxicity following zinc pretreatment. Toxicol Appl Pharmacol. 1992;113:227–33.
Early JL, Schnell RC. Selenium antagonism of cadmium-induced inhibition of hepatic drug metabolism in the male rat. Toxicol Appl Pharmacol. 1981;58:57–66.
Fariss MW. Cadmium toxicity: unique cytoprotective properties of alpha tocopheryl succinate in hepatocytes. Toxicology. 1991;69:63–77.
Flagel KM, Carry EF, Pond WG, Krook LP. Dietary selenium and cadmium interrelationship in growing swine. J Nutr. 1980;110:1255–61.
Friberg L, Piscator M, Nordberg GF, Kjellstron T. Cadmium in the environment, 2nd ed. CRC Press, Cleveland, OH; 1974:137–69.
Gasiewicz TA, Smith JC. Properties of the cadmium and selenium complex formed in rat plasmain vivo andin vitro. Chem-Biol Interact. 1978;23:171–83.
Gick GG, McCarty KS Jr, McCarty KD Sr. The role of metallothionein synthesis in cadmium- and zinc-resistant CHO-K1M cells. Exp Cell Res. 1981;132:23–30.
Gunn SA, Gould TC, Anderson WAD. Cadmium-induced interstitial cell tumors in rats and mice and their prevention by zinc. J Natl Cancer Inst. 1963;31:745–59.
Gunn SA, Gould TC, Anderson WAD. Selectivity of organ response to cadmium injury and various protective measures. J Pathol Bacteriol. 1968;96:89–96.
Hagino N, Yoshioka K. A study on the cause of Itai-itai disease. J Jpn Orthop Assoc. 1961;35:812–5.
Hart BA, Voss GW, Shatos MA, Doherty J. Cross-tolerance to hyperoxia following cadmium aerosol pretreatment. Toxicol Appl Pharmacol. 1990;103:255–70.
Hildebrand CE, Tobey RA, Compbell EW, Enger MD. A cadmium-resistant variant of the Chinese hamster (CHO) cell with increased metallothionein induction capacity. Exp Cell Res. 1979;124:237–46.
Hirano S, Tsukamoto N, Suzuki KT. Biochemical changes in the rat lung and liver following intratracheal instillation of cadmium oxide. Toxicol Lett. 1990;50:97–105.
Holt D, Magos L, Webb M. The interaction of cadmium-induced rat renal metallothionein with divalent mercuryin vitro. Chem-Biol Interact. 1980;32:125–35.
Hudecová A, Ginter E. The influence of ascorbic acid on lipid peroxidation in guinea pigs intoxicated with cadmium. Food Chem Toxicol. 1992;30:1011–3.
IARC. Cadmium and cadmium compounds. In: IARC monographs on the evaluation of carcinogenic risks to humans, vol. supplement 7. Lyon, France: IARC; 1987:139–42.
Jamall IS, Roque H. Cadmium-induced alterations in ocular trace elements. Influence of dietary selenium and copper. Biol Trace Elem Res. 1989;23:55–63.
Jamall IS, Smith JC. Effects of cadmium on glutathione peroxidase, superoxide dismutase, and lipid peroxidation in the rat heart: A possible mechanism of cadmium cardiotoxicity. Toxicol Appl Pharmacol. 1985;80:33–42.
Jamall IS, Sprowls JJ. Effects of cadmium and dietary selenium on cytoplasmic and mitochondrial antioxidant defense systems in the heart of rats fed high dietary copper. Toxicol Appl Pharmacol. 1987;87:102–10.
Kadima W, Rabenstein DL. A quantitative study of the complexation of cadmium in hemolyzed human erythrocytes by1H NMR spectroscopy. J Inorg Biochem. 1990a;40:141–9.
Kadima W, Rabenstein DL. Nuclear magnetic resonance studies of the solution chemistry of metal complexes. 26. Mixed ligand complexes of cadmium, nitrilotriacetic acid, glutathione, and related ligands. J Inorg Biochem. 1990b;38:277–88.
Kadrabova J, Madaric A, Ginter E. The effect of ascorbic acid on cadmium accumulation in guinea pig tissues. Experientia. 1992;48:989–91.
Kang YJ, Enger MD. Effect of cellular glutathione depletion on cadmium-induced cytotoxicity in human lung carcinoma cells. Cell Biol Toxicol. 1987;3:347–60.
Kang YJ, Enger MD. Cadmium cytotoxicity correlates with the changes in glutathione content that occur during the logarithmic growth phase of A549-T27 cells. Toxicol Lett. 1990;51:23–8.
Kang YJ, Clapper JA, Enger MD. Enhanced cadmium cytotoxicity in A549 cells with reduced glutathione levels is due to neither enhanced cadmium accumulation nor reduced metallothionein synthesis. Cell Biol Toxicol. 1989;5:249–59.
Kang YJ, Nuutero ST, Clapper JA, Jenkins P, Enger MD. Cellular cadmium responses in subpopulations T20 and T27 of human lung carcinoma A549 cells. Toxicology. 1990;61:195–203.
Kofod P, Bauer R, Danielsen E, Larsen E, Bjerrum MJ.113Cd-NMR investigation of a cadmium-substituted copper, zinc-containing superoxide dismutase from yeast. Eur J Biochem. 1991;198:607–11.
Koizumi T, Li ZG. Role of oxidative stress in single-dose, cadmium-induced testicular cancer. J Toxicol Environ Health. 1992;37:25–36.
Koizumi T, Li ZG, Tatsumoto H. DNA damaging activity of cadmium in Leydig cells, a target cell population for cadmium carcinogenesis in the rat testis. Toxicol Lett. 1992;63:211–20.
Kojima S, Ishihara N, Hirukawa H, Kiyozumi M. Effect ofN-benzyl-D-glucamine dithiocarbamate on lipid peroxidation in testes of rats treated with cadmium. Res Commun Chem Pathol Pharmacol. 1990;67:259–69.
Liu J, Kershaw WC, Klassen CD. The protective effect of metallothionein on the toxicity of various metals in rat primary hepatocyte culture. Toxicol Appl Pharmacol. 1991;107:27–34.
Magos L, Webb M. Differences in distribution and excretion of selenium and cadmium or mercury after their simultaneous administration subcutaneously in equimolar doses. Arch Toxicol. 1976;36:63–9.
Manca D, Ricard AC, Trottier B, Chevalier G. Studies on lipid peroxidation in rat tissues following administration of low and moderate doses of cadmium chloride. Toxicology. 1991;67:303–23.
Martins EAL, Chubatsu LS, Meneghini R. Role of antioxidants in protecting cellular DNA from damage by oxidative stress. Mutat Res. 1991;250:95–101.
Mason KE, Young JO, Brown JA. Effectiveness of selenium and zinc in protecting against cadmium-induced injury in the rat testis. Anat Rec. 1964;148:309.
Mello-Filho AC, Chubatsu LS, Meneghini R. V79 Chinese hamster cells rendered resistant to high cadmium concentration also become resistant to oxidative stress. Biochem J. 1988;256:475–9.
Merali Z, Singhal RL. Protective effect of selenium on certain hepatotoxic and pancreatic manifestations of subacute cadmium administration. J Pharmacol Exp Ther. 1975;195:58–66.
Minami M, Koshi K, Homma K, Suzuki Y. Changes of the activity of superoxide dismutase after exposure to the fumes of heavy metals and the significance of zinc in the tissue. Arch Toxicol. 1982;49:215–25.
Mukherjee A, Sharma A, Talukder G. Effect of selenium on cadmium-induced chromosomal aberrations in bone marrow cells of mice. Toxicol Lett. 1988;41:23–9.
Müller L. Protective effects ofDL-alpha-lipoic acid on cadmium-induced deterioration of rat hepatocytes. Toxicology. 1989;58:175–85.
Müller L, Menzel H. Studies on the efficacy of lipoate and dihydrolipoate in the alteration of cadmium2+ toxicity in isolated hepatocytes. Biochim Biophys Acta. 1990;1052:386–91.
Müller T, Schuckelt R, Jaenicke L. Cadmium/zincmetallothionein induces DNA strand breaksin vitro. Arch Toxicol. 1991 65:20–6.
Nomiyama K, Nomiyama H, Nomura Y et al. Effects of dietary cadmium on rhesus monkeys. Environ Health Perspect. 1979;28:223–43.
Ochi T. Cadmium-resistant Chinese hamster V79 cells with decreased accumulation of cadmium. Chem-Biol Interact. 1991;78:207–21.
Ochi T, Ohsawa M. Participation of active oxygen species in the induction of chromosomal aberrations by cadmium chloride in cultured Chinese hamster cells. Mutat Res. 1985;143:137–42.
Ochi T, Ishiguro T, Ohsawa M. Participation of active oxygen species in the induction of DNA single-strand breaks scissions by cadmium chloride in cultured Chinese hamster cells. Mutat Res. 1983;122:169–75.
Ochi T, Takahashi K, Ohsawa M. Indirect evidence for the induction of a prooxidant state by cadmium chloride in cultured mammalian cells and a possible mechanism for the induction. Mutat Res. 1987;180:257–66.
Omaye ST, Tappel AL. Effect of cadmium chloride on the rat testicular soluble selenoenzyme, glutathione peroxidase. Res Commun Chem Pathol Pharmacol. 1975;12:695–711.
Pharikal K, Das PC, Dey CD, Dasgupta S. Tissue ascorbate as a metabolic marker in cadmium toxicity. Int J Vitam Nutr Res. 1988;58:306–11.
Probst FA, Bousquet WF, Miya TS. Correlation of hepatic metallothionein concentrations with acute cadmium toxicity in the mouse. Toxicol Appl Pharmacol. 1977;39:61–9.
Prohaska JR, Mowafy M, Ganther HD. Interactions between cadmium, selenium and glutathione peroxidase in rat testis. Chem-Biol Interact. 1977;18:253–65.
Rugstad HE, Norseth T. Cadmium resistance and content of cadmium-binding protein in cultured human cells. Nature. 1975;257:136–7.
Rugstad HE, Norseth T. Cadmium resistance and content of cadmium-binding protein in two enzyme-deficient mutants of mouse fibroblasts (L-cells). Biochem Pharmacol. 1978;27:647–50.
Sharma G, Nath R, Gill KD. Effect of ethanol on cadmium-induced lipid peroxidation and antioxidant enzymes in rat liver. Biochem Pharmacol. 1991;42:S9-S16.
Sheabar FZ, Yannai S. Extracorporeal complexation and haemodialysis for the treatment of cadmium poisoning. I. Effects of four chelators on thein vitro elimination of cadmium from human blood. Pharmacol Toxicol. 1989;64:257–61.
Shimizu M, Morita S. Effects of fasting on cadmium toxicity, glutathione metabolism, and metallothionein synthesis in rats. Toxicol Appl Pharmacol. 1990;103:28–39.
Shinno JA. Cadmium-induced alterations in the antioxidant defense system of the rat eye in relation to dietary selenium intake. Biol Trace Elem Res. 1989;20:153–9.
Shukla GS, Chandra SV. Cadmium toxicity and bioantioxidants: status of vitamin E and ascorbic acid of selected organs in rats. J Appl Toxicol. 1989;9:119–22.
Shukla GS, Hussain T, Chandra SV. Possible role of regional superoxide dismutase activity and lipid peroxide levels in cadmium neurotoxicity:in vivo andin vitro studies in growing rats. Life Sci. 1987;41:2215–21.
Singhal RK, Anderson ME, Meister A. Glutathione, a first line defense against cadmium toxicity. FASEB J. 1987;1:220–3.
Snyder RD. Role of active oxygen species in metal-induced DNA strand breakage in human diploid fibroblasts. Mutat Res. 1988;193:237–46.
Stacey NH. The amelioration of cadmium-induced injury in isolated hepatocytes by reduced glutathione. Toxicology. 1986;42:85–92.
Sugawara N, Hirohata Y, Sugawara C. Testicular dysfunction induced by cadmium and its improvement caused by selenium in the mouse. J Environ Pathol Toxicol Oncol. 1989;9:54–63.
Sugiyama M, Tsuzuki K, Haramaki N. DNA single strand breaks and cytotoxicity induced by sodium chromate(VI) in hydrogen peroxide resistant cell lines. Mutat Res. 1993;299:95–102.
Takenaka S, Oldiges H, Konig H, Hochrainer D, Oberdörster G. Carcinogenicity of cadmium chloride aerosols in W rats. J Natl Cancer Inst. 1983;70:367–71.
Tandon SK, Singh S, Dhawan M. Preventive effect of vitamin E in cadmium intoxication. Biomed Environ Sci. 1992;5:39–45.
Thornalley PJ, Vasak M. Possible role for metallothionein in protection against radiation induced oxidative stress. Kinetics and mechanisms of its reaction with superoxide and hydroxyl radicals. Biochim Biophys Acta. 1985;827:36–44.
Vleet JFV, Boon GD, Ferrans VJ: Induction of lesions of selenium-vitamin E deficiency in ducklings fed silver, copper, cobalt, tellurium, cadmium, or zinc: protection by selenium or vitamin E supplements. Am J Vet Res. 1981;42:1206–17.
Waalkes MP, Perantoni A. Isolation of a novel metal-binding protein from rat testes: Characterization and distinction from metallothionein. J Biol Chem. 1986;261:13079–103.
Waalkes MP, Rehm S, Riggs CW et al. Cadmium carcinogenesis in male Wistar [Crl:(WI)BR] rats: Dose-response analysis of tumor induction in the prostate and testes, and at the injection site. Cancer Res. 1988;48:4656–63.
Waalkes MP, Rehm S, Riggs CW et al. Cadmium carcinogenesis in male Wistar [Crl: (WI)BR] rats: Dose-response analysis of effects of zinc on tumor induction in the prostate, in the testes, and at the injection site. Cancer Res. 1989;49:4282–8.
Waalkes MP, Oberdörster G. Cadmium carcinogenesis. In: Foulkes E, ed. Biological effects of heavy metals, vol. II: Mechanisms of metal carcinogenesis. Boca Raton, FL: CRC Press; 1990:129–57.
Wahba ZZ, Hernandez L, Issaq HJ, Waalkes MP. Involvement of sulfhydryl metabolism in tolerance to cadmium in testicular cells. Toxicol Appl Pharmacol. 1990;104:157–66.
Walters RA, Enger MD, Hildebrand CE, Griffith JK. Genes coding for metal induced synthesis of RNA sequences are differently amplified and regulated in mammalian cells. In: Brown DD, Fox CF, eds. Developmental biology using purified genes. New York: Academic Press; 1981. (ICN-UCLA symposia on molecular and cellular biology, vol. XXIII).
Webb M. Binding of cadmium ions by rat liver and kidney. Biochem Pharmacol. 1972;21:2751–65.
Zhong Z, Troll W, Koenig KL, Frenkel K. Carcinogenic sulfide salts of nickel and cadmium induce H2O2 formation by human polymorphonuclear leukocytes. Cancer Res. 1990;50:7564–70.
Mercury
Baggett JM, Berndt WO. The effect of depletion of nonprotein sulfhydryls by diethyl maleate plus buthionine sulfoximine on renal uptake of mercury in the rat. Toxicol Appl Pharmacol. 1986;83:556–62.
Benov LC, Benchev IC, Monovich OH. Thiol antidotes effect on lipid peroxidation in mercury-poisoned rats. Chem-Biol Interact. 1990;76:321–32.
Betti C, Davini T, Barale R. Genotoxic activity of methyl mercury chloride and bimethyl mercury in human lymphocytes. Mutat Res. 1992;281:255–60.
Cantoni O, Evans RM, Costa M. Similarity in the cytotoxic response of mammalian cells to mercury(II) and x-rays: DNA damage and glutathione depletion. Biochem Biophys Res Commun. 1982;108:614–9/
Cantoni O, Christie NT, Swann A, Drath DB, Costa M. Mechanism of HgCl2 cytotoxicity in cultured mammalian cells. Mol Pharmacol. 1984;26:360–8.
Costa M, Christie NT, Cantoni O, Zelikoff JT, Wang XW, Rossman TG. DNA damage by mercury compounds: an overview. In: Suzuki T, ed. Advances in mercury toxicology. New York: Plenum Press; 1991:255–73.
Di Simplicio P, Gorelli M, Ciuffreda P, Leonzio C. The relationship between gamma-glutamyl transpeptidase and Hg levels in Se/Hg antagonism in mouse liver and kidney. Pharmacol Res. 1990;22:515–26.
Dutczak WJ, Ballatori N. Gamma-glutamyltransferase-depenent biliary-hepatic recycling of methyl mercury in the guinea pig. J Pharmacol Exp Ther. 1992;262:619–23.
Dutczak WJ, Clarkson TW, Ballatori N. Biliary-hepatic recycling of a xenobiotic: gallbladder absorption of methyl mercury. Am J Physiol. 1991;260:G873–80.
Ganther HE. Modification of methylmercury toxicity and metabolism by selenium and vitamin E: possible mechanisms. Environ Health Perspect. 1978;25:71–6.
Ganther HE. Interactions of vitamin E and selenium with mercury and silver. Ann NY Acad Sci. 1980;355:212–6.
Girardi G, Elias MM. Effectiveness ofN-acetylcysteine in protecting against mercuric chloride-induced nephrotoxicity. Toxicology. 1991;67:155–64.
Gyurasics A, Varga F, Gregus Z. Effect of arsenicals on biliary excretion of endogenous glutathione and xenobiotics with glutathione-dependent hepatobiliary transport. Biochem Pharmacol. 1991;41:937–44.
Houser MT, Milner LS, Kolbeck PC, Wei SH, Stohs SJ. Glutathione monoethyl ester moderates mercuric chloride-induced acute renal failure. Nephron. 1992;61:449–55.
Johnson DR. Role of renal cortical sulfhydryl groups in development of mercury-induced renal toxicity. J Toxicol Environ Health. 1982;9:119–26.
Kerper LE, Ballatori N, Clarkson TW. Methylmercury transport across the blood-brain barrier by an amino acid carrier. Am J Physiol. 1992;262:R761–5.
Kojima K, Fujita M. Summary of recent studies in Japan on methyl mercury poisoning. Toxicology. 1973;1:43–62.
Kudo A, Miyahara S. Effect of decontamination project at Minamata bay, Japan. Ecotoxicol Environ Saf. 1988;15:339–43.
Liu Y, Cotgreave I, Atzori L, Grasfstrom RC. The mechanism of Hg2+ toxicity in cultured human oral fibroblasts: the involvement of cellular thiols. Chem-Biol Interact. 1992;85:69–78.
Livardjani F, Ledig M, Kopp P, Dahlet M, Leroy M, Jaeger A. Lung and blood superoxide dismutase activity in mercury vapor exposed rats: effect ofN-acetylcysteine treatment. Toxicology. 1991;66:289–95.
Lund B-O, Miller DM, Woods JS. Mercury-induced H2O2 production and lipid peroxidationin vitro in rat kidney mitochondria. Biochem Pharmacol. 1991;42 Suppl:S181–7.
Molin M, Bergman B, Marklund SL, Schutz A, Skerfving S. Mercury, selenium, and glutathione peroxidase before and after amalgam removal in man. Acta Odontol Scand. 1990;48:189–202.
Naganuma A, Anderson ME, Meister A. Cellular glutathione as a determinant of sensitivity to mercuric chloride toxicity. Prevention of toxicity by giving glutathione monoester. Biochem Pharmacol. 1990;40:693–7.
Richardson RJ, Murphy SD Effect of glutathione depletion on tissue deposition of methylmercury in rats. Toxicol Appl Pharmacol. 1975;31:505–19.
Sarafian T, Verity MA. Oxidative mechanisms underlying methyl mercury neurotoxicity. Int J Dev Neurosci. 1991;9:147–53.
Study Group of Minamata Disease. Minamata disease. Japan: Kumamoto University; 1968.
Suda I, Totoki S, Takahashi H Degradation of methyl and ethyl mercury into inorganic mercury by oxygen free radical-producing systems: involvement of hydroxyl radical. Arch Toxicol. 1991;65:129–34.
Suda I, Takahashi H. Degradation of methyl and ethyl mercury into inorganic mercury by other reactive oxygen species besides hydroxyl radical. Arch Toxicol. 1992;66:34–9.
Sugiyama M, Tsuzuki K, Haramaki N. DNA single strand breaks and cytotoxicity induced by sodium chromate(VI) in hydrogen peroxide resistant cell lines. Mutat Res. 1993;299:95–102.
Tanaka T, Naganuma A, Imura N. Role of gamma-glutamyltranspeptidase in renal uptake and toxicity of inorganic mercury in mice. Toxicology. 1990;60:187–98.
Tanaka T, Naganuma A, Kobayashi K, Imura N. An explanation for strain and sex differences in renal uptake of methylmercury in mice. Toxicology. 1991;69:317–29.
Tanaka-Kagawa T, Naganuma A, Imura N. Tubular secretion and reabsorption of mercury compounds in mouse kidney. J Pharmacol Exp Ther. 1993;264:776–82.
Vimy MJ, Lorscheider FL. Intra-oral air mercury released from dental amalgam. J Dent Res. 1985;64:1069–71.
Watanabe T, Shimada T, Endo A. Effects of mercury compounds on ovulation and meiotic and mitotic chromosome division in female golden hamster. Teratology. 1982;25:381–4.
Woods JS, Calas CA, Aicher LD, Robinson BH, Mailer C. Stimulation of porphyrinogen oxidation by mercuric ion. I. Evidence of free radical formation in the presence of thiols and hydrogen peroxide. Mol Pharmacol. 1990a;38:253–60.
Woods JS, Calas CA, Aicher LD. Stimulation of porphyrinogen oxidation by mercuric ion. II Promotion of oxidation from the interaction of merouric ion, glutathione, and mitochondria-generated hydrogen peroxide. Mol Pharmacol. 1990b;38:261–6.
Woods JS, Davis HA, Baer NP. Enhancement of gammaglutamylcysteine synthetase mRNA in rat kidney by methyl mercury. Arch Biochem Biophys 1992;296:350–3.
Yasutake A, Hirayama K, Inoue M. Mechanism of urinary excretion of methylmercury in mice. Arch Toxicol. 1989;63:479–83.
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Sugiyama, M. Role of cellular antioxidants in metal-induced damage. Cell Biol Toxicol 10, 1–22 (1994). https://doi.org/10.1007/BF00757183
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DOI: https://doi.org/10.1007/BF00757183