Abstract
Glass-ceramic A-W containing crystalline apatite and wollastonite in an MgO-CaO-SiO2 glassy matrix bonds to living bone through an apatite layer which is formed on its surface in the body. The parent glass G of glass-ceramic A-W and glass-ceramic A, which has the same composition as glass-ceramic A-W but contains only the apatite, also bond to living bone through the surface apatite layer, whereas glass-ceramic A-W(Al), which contains the apatite and wollastonite in an MgO-CaO-SiO2-Al2O3 glassy matrix, neither forms the surface apatite layer nor bonds to living bone. In the present study, in order to reveal the mechanism of formation of the surface apatite layer, changes in ion concentrations of a simulated body fluid with immersion of these four kinds of glass and glass-ceramics were investigated. Bioactive glass G and glass-ceramics A and A-W all showed appreciable increases in Ca and Si concentrations, accompanied by an appreciable decrease in P concentration, whereas non-bioactive glass-ceramic A-W(Al) hardly showed any element concentration change. It was speculated from these results that dissolution of the Ca(II) and Si(IV) ions from bioactive glass and glass-ceramics plays an important role in forming the apatite layer on their surfaces in the body.
Article PDF
Similar content being viewed by others
Explore related subjects
Discover the latest articles, news and stories from top researchers in related subjects.Avoid common mistakes on your manuscript.
References
T. KOKUBO, M. SHIGEMATSU, Y. NAGASHIMA, M. TASHIRO, T. NAKAMURA, T. YAMAMURO and S. HIGASHI,Bull. Inst. Chem. Res., Kyoto Univ. 60 (1982) 260.
T. KOKUBO, S. ITO, S. SAKKA and T. YAMAMURO,J. Mater. Sci. 21 (1986) 536.
T. KOKUBO, S. ITO, M. SHIGEMATSU, S. SAKKA and T. YAMAMURO, ibid.20 (1985) 2001.
Idem, ibid.22 (1987) 4067.
T. KITSUGI, T. YAMAMURO, T. NAKAMURA, Y. KAKUTANI, T. HAYASHI, S. ITO, T. KOKUBO, M. TAKAGI and T. SHIBUYA,J. Biomed. Mater. Res. 21 (1987) 467.
T. NAKAMURA, T. YAMAMURO, S. HIGASHI, T. KOKUBO and S. ITO, ibid.19 (1985) 685.
S. YOSHII, Y. KAKUTANI, T. YAMAMURO, T. NAKAMURA, T. KITSUGI, M. OKA, T. KOKUBO and M. TAKAGI, ibid.22 (1988) 327.
T. KITSUGI, T. YAMAMURO, T. NAKAMURA, S. HIGASHI, Y. KAKUTANI, K. HYAKUNA, S. ITO, T. KOKUBO, M. TAKAGI and T. SHIBUYA, ibid.20 (1986) 1295.
T. KITSUGI, T. NAKAMURA, T. YAMAMURO, T. KOKUBO, T. SHIBUYA and M. TAKAGI, ibid.21 (1987) 1255.
T. KOKUBO, C. OHTSUKI, S. KOTANI, T. KITSUGI and T. YAMAMURO, in “Bioceramics”, Vol. 2, edited by G. Heimke (German Ceramic Society, Cologne, 1990) p. 113.
T. KITSUGI, T. YAMAMURO, T. NAKAMURA and T. KOKUBO,J. Biomed. Mater. Res. 23 (1989) 631.
Idem,,Internatl Orthopaedics 13 (1989) 199.
L. L. HENCH, in “Fundamental Aspects of Biocompatibility”, Vol. 1, edited by D. F. Williams (CRC Press, Boca Raton, 1981) p. 67.
L. L. HENCH and A. E. CLARK, in “Biocompatibility of Orthopaedic Implants”, Vol. II, edited by D. F. Williams (CRC Press, Boca Raton, 1982) p. 129.
S. KOTANI, T. YAMAMURO, T. NAKAMURA, T. KITSUGI, Y. FUJITA, K. KAWANABE, T. KOKUBO and C. OHTSUKI, in “Bioceramics”, Vol. 2, edited by G. Heimke (German Ceramic Society, Cologne, 1990) p. 105.
T. KOKUBO, T. HAYASHI, S. SAKKA, T. KITSUGI, T. YAMAMURO, M. TAKAGI and T. SHIBUYA, in “Ceramics in Clinical Applications”, edited by P. Vincenzini (Elsevier, Amsterdam, 1987) p. 175.
T. KOKUBO, S. ITO, Z. T. HUANG, T. HAYASHI, S. SAKKA, T. KITSUGI and T. YAMAMURO,J. Biomed. Mater. Res. 24 (1990) 331.
T. KOKUBO, H. KUSHITANI, S. SAKKA, T. KITSUGI and T. YAMAMURO, ibid.24 (1990) 721.
C. OHTSUKI, H. KUSHITANI, T. KOKUBO, S. KOTANI and T. YAMAMURO, ibid.25 (1991) 1363.
T. KOKUBO, S. ITO, M. SHIGEMATSU, T. NAKAMURA, T. YAMAMURO and S. HIGASHI,Glastechn. Ber. 56K 1 (1983) 695.
J. GAMBLE, in “Chemical Anatomy, Physiology and Pathology of Extracellular Fluid”, 6th Edn (Harvard University Press, Cambridge, 1967) p. 1.
W. NEUMAN and M. NEUMAN, in “The Chemical Dynamics of Bone Mineral” (University of Chicago, Chicago, 1958) p. 175.
A. PAUL,J. Mater. Sci. 12 (1977) 2246.
R. G. BATES,J. Res. Natl. Bur. Stand. 47 (1951) 127.
R. G. BATES and S. F. ACREE, ibid.30 (1943) 129.
C. E. VADERZEE and A. S. QUIST,J. Phys. Chem. 65 (1961) 118.
A. CHUGHTAI, R. MARSHALL and G. H. NANCOLLAS, ibid.72 (1968) 208.
H. McDOWELL, T. M. GREGORY and W. E. BROWN,J. Res. Natl. Bur. Stand. 81A (1977) 273.
E. M. CARLISLE, in “Silicon Biochemistry”, Ciba Foundation Symposium 121 (Wiley, Chichester, 1986) p. 123.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kokubo, T., Kushitani, H., Ohtsuki, C. et al. Chemical reaction of bioactive glass and glass-ceramics with a simulated body fluid. J Mater Sci: Mater Med 3, 79–83 (1992). https://doi.org/10.1007/BF00705272
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00705272