Summary
Electron microscopic examinations were carried out in the brains of cats with acute arterial hypertension produced by intermittent compression of the descending aorta.
The ultrastructural changes included swelling of the astrocytic processes, dilatation of the endoplasmic reticulum, and slight enlargement of the extracellular space of the white matter. Swelling of the mitochondria with disruption of the cristae was sometimes observed. The extracellular space of the gray matter showed no expansion.
The changes in the ultrastructure of the central nervous system in hypertensive and ischemic encephalopathy were found to be very similar. This finding is discussed with special regard to the pathogenesis of acute hypertensive encephalopathy.
Zusammenfassung
Es wurden elektronenmikroskopische Untersuchungen am Gehirn von Katzen bei akuter Hypertonie, die durch wechselnde Kompression der absteigenden Aorta erzeugt wurde, ausgeführt.
Die ultrastrukturellen Veränderungen umfaßten Schwellung der Astrocytenausläufer, Erweiterung des endoplasmatischen Reticulums, und geringe Erweiterung des Extracellulärraumes des Gehirnmarks. Manchmal wurde auch Schwellung der Mitochondrien mit Zerstörung der Cristae beobachtet. Der Extracellulärraum der Gehirnrinde zeigte keine Erweiterung.
Die Veränderungen in der Ultrastruktur des Zentralnervensystems werden im Hinblick auf die Pathogenese der hypertonischen Encephalopathie diskutiert.
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Supported by research grant NB 03754-06 from the National Institute of Neurological Diseases and Blindness.
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Kung, P.C., Lee, J.C. & Bakay, L. Electron microscopic study of experimental acute hypertensive encephalopathy. Acta Neuropathol 10, 263–272 (1968). https://doi.org/10.1007/BF00690702
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DOI: https://doi.org/10.1007/BF00690702