Summary
The morphology, incidence and distribution of senile plaques in the brain stem were examined in 15 cases of Alzheimer's disease, using mainly the Methenamine-Bodian method. The plaques were found in all cases and were grouped into three types according to their morphology. They were not randomly scattered in the brain stem, but had a distribution common to all cases. There were numerous plaques in the periaqueductal gray, superior colliculus, fourth-ventricle floor and superior central nucleus. The plaques were also found less abundantly in the reticular formation, substantia nigra, pontine nucleus and inferior olivary nucleus. There was a tendency for certain plaque types to be associated with specific regions. In the familial cases, the plaques tended to occur even in the regions where they were rare in other cases. The capillaries with plaque-like degeneration were observed not infrequently in the brain stem. The distribution of plaques did not always coincide with that of neurofibrillary tangles.
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Armstrong DM, Bruce G, Hersh LB, Terry RD (1986) Choline acetyltransferase immunoreactivity in neuritic plaques of Alzheimer brain. Neurosci Lett 71:229–234
Braunmühl AV (1957) Alterserkrankungen des Zentralnervensystems, senile Involution, senile Demenz, Alzheimersche Krankheit. In: Lubarsch O, Henke F, Rossle R (eds) Handbuch der speziellen pathologischen Anatomie und Histologie, vol 13. Springer, Berlin, pp 337–539
Dayan AD (1970) Quantitative histological studies on the aged human brain. II. Senile plaques and neurofibrillary tangles in senile dementia. Acta Neuropathol (Berl) 16:95–102
Fukatsu R, Ikeda T, Ueno T, Tanabe M, Honma H, Kimura N, Takahata N (1980) An unusual case of presenile dementia with numerous argentophilic plaques and severe amyloid vascular changes. Adv Neurol Sci 24:271–282
Gibson PH (1983) Form and distribution of senile plaques seen in silver-impregnated sections in the brains of intellectually normal elderly people and people with Alzheimer-type dementia. Neuropathol Appl Neurobiol 9:379–389
Hirano A, Zimmerman HM (1962) Silver impregnation of nerve cells and fibers in celloidin sections. Arch Neurol 6:114–122
Hirano A, Zimmerman HM (1962) Alzheimer's neurofibrillary changes: a topographic study. Arch Neurol 7: 277–242
Ishii T (1966) Distribution of Alzheimer's neurofibrillary changes in the brain stem and hypothalamus of senile dementia. Acta Neuropathol (Berl) 6:181–187
Ishii T, Haga S, Kitaguchi N (1987) Immunohistochemistry and molecular biology of Glenner amyloid protein (GP). Neuropathology 8:173
Kitt CA, Strube RG, Cork LC, Mobley WC, Walker LC, Joh TH, Price DL (1985) Catecholaminergic neurites in senile plaques in prefrontal cortex of aged nonhuman primates. Neuroscience 16:691–699
Kondo H, Haga C, Kito T, Kosaka K, Matsushita M (1987) The Methenamine-Bodian staining for the demonstration of senile plaques. Byori-to-Rinsho 5:1365–1369
Makifuchi T, Watabe K, Ikuta F (1986) The study of senile plaques by the PAM staining: the detection of amyloid. Neuropathology 7:196
Mandybur TI (1975) The incidence of cerebral amyloid angiopathy in Alzheimer's disease. Neurology 25:120–126
Matsuoka T, Miyoshi K, Saka K, Kawagoe T, Nishikiori T, Suzuki S, Hirabayashi M, Shisozuka T, Suda K, Aoki A, Shimokawa K, Shiraki H (1967) A case of encephalopathy with plaque-like bodies, neurofibrillary change, angiopathy and amyotrophic lateral sclerosis-like lesions. Adv Neurol Sci 11:801–811
Miyakawa T, Shimoji A, Kuramoto R, Higuchi Y (1982) The relationship between senile plaques and cerebral blood vessels in Alzheimer's disease and senile dementia. Morphological mechanism of senile plaques production. Virchows Arch [B] 40:121–129
Morioka E (1985) Senile amyloid changes in the cerebellum: with special reference to senile plaques and amyloid angiopathy. Neuropathology 6:313–323
Morrison JH, Rogers J, Scherr S, Benoit R, Bloom FE (1985) Somatostatin immunoreactivity in neuritic plaques of Alzheimer's patient. Nature 314:90–92
Mountjoy CQ, Tomlinson BE, Gibson PH (1982) Amyloid and senile plaques and cerebral blood vessels: a semiquantitative investigation of a possible relationship. J Neurol Sci 57:89–103
Rogers J, Morrison JH (1985) Quantitative morphology and regional and laminar distributions of senile plaques in Alzheimer's disease. J Neurosci 5:2801–2808
Rudelli RD, Ambler MW, Wisniewski HM (1984) Morphology and distribution of Alzheimer neuritic (senile) and amyloid plaques in striatum and diencephalon. Acta Neuropathol (Berl) 64:273–281
Rudelli RD, Ambler MW, Wisniewski HM (1984) Pattern of distribution of Alzheimer plaques in brain stem. J Neuropathol Exp Neurol 43:306
Scholz W (1938) Studien zur Pathologie der Hirngefäße. II. Die drusige Entartung der Hirnarterien und Capillaren. Z Neurol 162:694–715
Tomlinson BE, Corsellis JAN (1984) Ageing and the dementias. In: Adams JH, Corsellis JAN, Duchen LW (eds) Greenfield's neuropathology, 4th edn. Edward Arnold, London, pp 951–1025
Tomonaga M (1981) Cerebral amyloid angiopathy in the elderly. J Am Geriatr Soc 29:151–157
Wisniewski HM, Terry RD (1973) Reexamination of the pathogenesis of the senile plaque. Prog Neuropathol 11:1–26
Wong CW, Quaranta V, Glenner GG (1985) Neuritic plaques and cerebrovascular amyloid in Alzheimer's disease are antigenically related. Proc Natl Acad Sci USA 82: 8729–8732
Worster-Drought C, Greenfield JG, McMenemey WH (1944) A form of familial presenile dementia with spastic paralysis. Brain 67:38–43
Yajima G (1976) The periodic acid-methenamine silver staining for renal glomeruli. Rinsho-Kensa 20:14–19.
Yamamoto T, Hirano A (1986) A comparative study of modified Bielschowsky, Bodian and thioflavin S stains on Alzheimer's neurofibrillary tangles. Neuropathol Appl Neurobiol 12:3–9
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Iseki, E., Matsushita, M., Kosaka, K. et al. Distribution and morphology of brain stem plaques in Alzheimer's disease. Acta Neuropathol 78, 131–136 (1989). https://doi.org/10.1007/BF00688200
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DOI: https://doi.org/10.1007/BF00688200