Summary
Amyloid fibrils and senile plaques in brains with Alzheimer's disease, senile dementia and Down's syndrome were examined by light and electron microscopy. In addition, replicas of amyloid fibrils, made by a quick freezing method from a brain with Down's syndrome, were examined. All amyloid masses forming the cores of senile plaques consisted of numerous amyloid fibrils spreading from the walls of small blood vessels to the surrounding parenchyma. The amyloid fibrils ran in various directions, forming bundle-like groups in a geometrical array. They appeared as rods with hollow structures consisting of an array of globular units in the replicas, while they showed bead-like structure in the tissue specimens of 500-nm thick sections. The ultrastructure of replicas reveals a new finding on the structure of amyloid fibrils in the human brain.
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Corsellis JAN, Brierly JB (1954) An unusual type of presenile dementia. Brain 77:571–587
De Armond SJ, McKinley MP, Barry RA, Braunfeld MB, McColloch JR, Prusiner SB (1985) Identification of prion amyloid filaments in scrapie-infected brain. Cell 41:221–235
Friede RL, Magee KR (1962) Alzheimer's disease: presentation of a case with pathologic and enzymatic-histochemical observations. Neurology 12:213–222
Glenner GG (1979) Congophilic microangiopathy in the pathogenesis of Alzheimer's syndrome (presenile dementia). Med Hypotheses 5:1231–1236
Glenner GG, Wong CW (1984a) Alzheimer's disease: Initial purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 122:885–890
Glenner GG, Wong CW (1984b) Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein. Biochem Biophys Res Commun 122:1131–1135
Glenner GG, Keiser HR, Bladen HA, Cuatrecasas P, Eanes ED, Ram JS, Kanfer JN, Delellis RA (1968) Amyloid. VI. A comparison of two morphologic components of human amyloid deposits. J Histochem Cytochem 16:633–644
Heuser JE, Reese TS, Dennis MJ, Jan Y, Jan L (1979) Synaptic vesicle exocytosis captured by quick freezing and correlated with quantal transmitter release. J Cell Biol 81:275–300
Hollander D, Strich SJ (1970) A typical Alzheimer's disease with congophilic angiopathy presenting with dementia of acute onset. In: Wolstenhome GEW, O'Connor M (eds) Alzheimer's disease. Churchill, London, pp 105–124
Miyakawa T, Uehara Y (1979) Observations of amyloid angiopathy and senile plaques by the scanning electron microscope. Acta Neuropathol (Berl) 48:153–156
Miyakawa T, Sumiyoshi S, Murayama E, Deshimaru M (1974) Ultrastructure of capillary plaque-like degeneration in senile dementia. Mechanism of amyloid production. Acta Neuropathol (Berl) 29:229–236
Miyakawa T, Shimoji A, Kuramoto R, Higuchi Y (1982) The relationship between senile plaques and cerebral blood vessels in Alzheimer's disease and senile dementia. Morphological mechanism of senile plaque production. Virchows Arch [Cell Pathol] 40:121–129
Morel F, Wildi E (1952) General and cellular pathochemistry of senile and presenile alterations of the brain. Proceedings of the 1st International Congress of Neuropathology, Rome. Casa Editrice Libraria, Rosenberg & Sellier, Torino, pp 347–374
Pantelakis S (1954) Un type particulier d' angiopathie sénile du système nerveaux central. Un angiopathie congophilie. Topographie et fréquences. Monatschr Psychiatr Neurol 198:219–256
Schlote W (1965) Die Amyloidnatur der kongophilen, drüsigen Entartung der Hirnarterien (Scholz) im Senium. Acta Neuropathol (Berl) 4:449–468
Scholz W (1938) Studien zur Pathologie der Hirngefäße in Senium. Proceedings of the 5th International Congress of Neuropathology, Zürich, pp 490–494
Shirahama T, Cohen AS (1967) High-resolution electron microscopic analysis of the amyloid fibrils. J Cell Biol 33:679–708
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Miyakawa, T., Katsuragi, S., Watanabe, K. et al. Ultrastructural studies of amyloid fibrils and senile plaques in human brain. Acta Neuropathol 70, 202–208 (1986). https://doi.org/10.1007/BF00686073
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DOI: https://doi.org/10.1007/BF00686073