Abstract
The application of cyclodextrin complexed drugs in non-oral dosage forms results in the following advantages:
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- The stability of volatile, chemically unstable drugs is significantly improved by transforming them into cyclodextrin complexes.
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- The transformation of oils, liquids into crystalline, solid state provides better physical, mechanical properties, easy to handle products.
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- Complex formation/encapsulation on molecular scale/remarkably enhances the dissolution and absorption of lipophylic drugs.
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- The formation of water soluble inclusion complexes makes possible the preparation of parenteral dosage forms without using organic solvents or detergents.
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Reference
Uekama, K.: Yakugaku Zasshi100 /9/. 903. 1980.
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Szente, L., Szejtli, J. & Gál-Füzy, M. Non-oral drug preparations containing cyclodextrin complexes. Journal of Inclusion Phenomena 2, 631–636 (1984). https://doi.org/10.1007/BF00662229
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DOI: https://doi.org/10.1007/BF00662229