Abstract
The preparation of benzalkonium chloride loaded microcapsules was performed by interfacial polycondensation of isocyanates. The present study was made in order to clarify parameters affecting microcapsule wall formation during the course of polymerization. The results presented here show that many interrelated parameters are involved during the microcapsule formation. Each individual component introduced in the preparation was shown to have an effect either on the morphology of the microcapsules or on the mechanical resistance. Benzalkonium chloride seemed to interact mainly in the interfacial polymer precipitation step through a salt effect, or influence the polycondensation reaction rate acting as a catalyst. A contribution of the hydroxylic functions of the surfactant in the polycondensation reaction of the isocyanate was also highlighted. Finally, the organic phase composition was found to be able to modulate the reactivity of hydroxylic functions of the surfactant, leading to very slow reactions in pure xylene. These effects were related to the characteristics of the microcapsules obtained according to different compositions of the formulation system.
Article PDF
Similar content being viewed by others
Explore related subjects
Discover the latest articles, news and stories from top researchers in related subjects.Avoid common mistakes on your manuscript.
References
Pharmacopae française Xème édition
Deasey PB (1984) In: Microencapsulation and Related Drug Processes. Marcel Dekker, New York, pp 61–91
Thies C (1987) In: Encyclopedia of Polymer Science and Engineering, 2nd ed. John Wiley & Son, Inc., vol. 9, pp 724–745
Arshady R (1989) J Microencapsulation 6:13–28
Arshady R (1990) Polym Eng Sci 30:905–914
Arshady R (1990) Polym Eng Sci 30:915–924
Green BK, Schleicher L (1956) US Patent 2,730,456; US Patent 2,730,457
Mahmoud HA, El-Samaligy (1985) Int J Pharm 25:121–133
Poncelet de Smet B, Poncelet D, Neufeld RJ (1990) Can J Chem Eng 68:443–447
Chang TMS (1972) In: Thomas CC (ed) Artificial Cells. Springfield, vol. III, pp 24–27
Kondo T (1978) In: Matijevic E. (ed) Surface and Colloid Science. Plenum Press, New York, vol. 10, pp 1–43
Wood DA, Whateley TL, Florence AT (1981) Int J Pharm 8:35–43
Morgan PW (1987) In: Encyclopedia of Polymer Science and Engineering, 2nd ed. John Wiley & Son, Inc., vol. 8, pp 221–237
Pearson RG (1985) J Polym Sci, Polym Chem 23:9–18
Pensé AM, Holtzscherer C, Benoit JP (1990) Eur Patent 90 401 742 3
Pensé AM, Vauthier C, Puisieux F, Benoit JP (1992) Int J Pharm 81:111–117
Taylor GA (1936) Proc R Soc A 157, 546, 565
Morgan PW, Kwolek SL (1959) J Polym Sci XL:299–327
Lyman DJ (1960) J Polym Sci 35:49–59
Brzozowski ZK, Dubczynski J, Petrus J (1979) J Macromol Sci Chem 7:875–886
Morgan PW (1981) J Macromol Sci Chem A15:683–699
McGinity JW, Martin A, Cuff GW, Combs AB (1981) J Pharm Sci 70:372–375
Scher HB (1979) US Patent 4 140 516
Burrell H (1975) In: J Brandrup, EH Immergut (eds) Polymer handbook 2nd ed., John Wiley, New York
Flory PJ (1946) Chem Rev 39:137–197
Brognolo G (1990) Speciality Chemicals, ICI Europa limited, Kortenberg Belgium
Oberth AE, Bruenner RS (1968) J Phys Chem 72:845–855
Hansen CM (1967) J Paint Technol 39:105–117
Davis TL, Farnum J McC (1934) J Am Chem Soc 56:883–885
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Pensé, A.M., Vauthier, C. & Benoit, J.P. Study of the interfacial polycondensation of isocyanate in the preparation of benzalkonium chloride loaded microcapsules. Colloid Polym Sci 272, 211–219 (1994). https://doi.org/10.1007/BF00658850
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00658850