Abstract
A series of experiments was performed to investigate the effects of corticotropin-releasing factor (CRF) on the amplitude of the acoustic startle response (ASR) in rats. Intracerebroventricular (ICV) administration of 1 μg rat CRF significantly potentiated acoustic startle amplitude; these effects were reversed in a dose-dependent manner by pretreatment with the benzodiazepine chlordiazepoxide (CDP). Doses of CDP that anatgonized CRF-potentiated ASR did not lower startle baseline or antagonize amphetamine-or strychnine-potentiated ASR. These results suggest that CRF has “anxiogenic” properties and may serve as a neuroendocrine modulator of stress-enhanced behaviors.
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Swerdlow, N.R., Geyer, M.A., Vale, W.W. et al. Corticotropin-releasing factor potentiates acoustic startle in rats: Blockade by chlordiazepoxide. Psychopharmacologia 88, 147–152 (1986). https://doi.org/10.1007/BF00652231
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DOI: https://doi.org/10.1007/BF00652231