Summary
The effects of 10-min intracoronary infusion of 10μg/kg/min adenosine on coronary and systemic haemodynamics, cardiac performance, myocardial CO2 and H+ balance and myocardial substrate metabolism were investigated in7 anaesthetized dogs. The following results were obtained.
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1.
During the adenosine infusion coronary blood flow rose 3-to 4-fold above the preinfusion value whereas the coronary AVD-O2 and coronary resistance fell. Cardiac oxygen consumption fell significantly during the first 5 min of infusion but rose thereafter to values exceeding the starting value. The aerobic efficiency of the heart was significantly increased during the first 7 min of the adenosine infusion.
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2.
The myocardial release of total CO2 was significantly diminished within the second minute and increased at the end of the adenosine infusion. Myocardial H+ release showed a tendency to increase during the first 7 min of infusion becoming significant if a correction was applied for the concomitant decrease in myocardial CO2 production.
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3.
Myocardial balance and OER values for FFA indicated a FFA release whereas glucose and pyruvate uptake were significantly increased during the whole infusion period. The myocardial lactate uptake and OER were significantly decreased between the 5th and 10th min of the infusion.
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4.
The temporal course of the decrease in myocardial lactate uptake and of the increase in myocardial flow was nearly identical. Myocardial glucose uptake showed a similar course but with a 2-min lag period. 5 min after the commencement of the adenosine infusion 34 μmoles/100 g more of glucose and 63 μmoles/100 g less of lactate (mean values) were taken up by the heart.
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5.
The results were interpreted on the basis of a glycolytic and lipolytic action of adenosine on the myocardium brought about by a stimulation of myocardial 3,5-AMP production. A connexion between the observed metabolic effects and the effects of adenosine on coronary resistance and flow is discussed and the myocardial metabolic acidosis as mediator in positive feedback control over myocardial metabolic processes and cardiac blood supply is stressed.
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Raberger, G., Kraupp, O., Stühlinger, W. et al. The effects of an intracoronary infusion of adenosine on cardiac performance, blood supply and on myocardial metabolism in dogs. Pflugers Arch. 317, 20–34 (1970). https://doi.org/10.1007/BF00586697
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DOI: https://doi.org/10.1007/BF00586697