Abstract
We attempted to analyze how\(P{\text{A}}_{{\text{CO}}_{\text{2}} } \)is regulated during progesterone-induced hyperventilation in the luteal phase. A model for the CO2 control loop was constructed, in which the function of the CO2 exchange system was described as\(P_{A_{CO_2 } } = 0.863 \times \dot V_{CO_2 } /\dot V_A {\text{ }}(gain{\text{ }}H = dP_{A_{CO_2 } } /d\dot V_A )\) and that of the CO2 sensing system as\(\dot V_A {\text{ = }}S{\text{(}}P_{{\text{A}}_{{\text{CO}}_{\text{2}} } } - B{\text{)}}\). Using this model, we estimated (1) the primary increase in\(\dot V_A (\Delta \dot V_A (op))\) produced by progesterone stimulation and (2) the effectiveness (E) of the loop to regulateP A CO 2, defined as ΔP A CO 2 (op)/ΔP A CO 2 (cl) in which op signifies open-loop and cl, closed-loop. These respiratory variables were investigated throughout the menstrual cycle in 8 healthy women. During the luteal phase, on average,\(\dot V_A \) increased by 9.4% andP A CO 2,B andH decreased by 0.33 kPa (2.5 mm Hg), 0.47 kPa (3.5 mm Hg) and 13.6%, respectively, whileS and\(\dot V_{CO_2 } \) did not change significantly. δ\(\Delta \dot V_A (op)\) (op) increased progressively on successive days of the luteal phase whileE remained unchanged at a value of 7.9, thus there was a progressive decrease inP A CO 2. The decrease inH was considered to lessen ΔP A CO 2 (op) and so reduce the final deviation ofP A CO 2 (ΔP A CO 2 (cl)) during the luteal phase. The decrease inB was found to be dependent on δ\(\Delta \dot V_A (op)\)(op).
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Takano, N., Sakai, A. & Iida, Y. Analysis of alveolar PCO 2 control during the menstrual cycle. Pflugers Arch. 390, 56–62 (1981). https://doi.org/10.1007/BF00582712
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DOI: https://doi.org/10.1007/BF00582712