Summary
After incubation with3H-noradrenaline, strips of human pulmonary arteries from patients undergoing surgery for lung tumour were superfused with physiological salt solution containing cocaine and corticosterone. Forskolin, AH 21-132 (a cAMP phosphodiesterase inhibitor), 8-Br-cAMP and isoprenaline did not affect the basal tritium efflux from the strips, but produced a concentration-dependent faciliatation of the tritium over-flow evoked by transmural electrical stimulation (2 Hz). The facilitatory effect of isoprenaline was potentiated by forskolin which produced a shift to the left of the concentration-response curve of isoprenaline. It is concluded that cAMP plays a role in the modulation of noradrenaline release in the human pulmonary artery and that presynapticβ-adrenoceptors appear to be coupled to an adenylate cyclase in the sympathetic nerve terminals.
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Hentrich, F., Göthert, M. & Greschuchna, D. Involvement of cAMP in modulation of noradrenaline release in the human pulmonary artery. Naunyn-Schmiedeberg's Arch. Pharmacol. 330, 245–247 (1985). https://doi.org/10.1007/BF00572440
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DOI: https://doi.org/10.1007/BF00572440