Summary
Eighteen of 38 examined families with children with Down's syndrome showed polymorphisms of chromosome 21 elucidating the origin of the extra chromosome 21. Maternal origin was found in 10 cases and paternal origin in 8 cases. In both sexes errors occurred both in the first and in the second meiotic division.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Craig-Holmes, A. P., Moore, F. B., Shaw, M. W.: Polymorphism of human C-band heterochromatin. II. Family studies with suggestive evidence for somatic crossing over. Amer. J. hum. Genet.27, 178–189 (1975)
Jenkins, R. L.: Etiology of mongolism. Amer. J. Dis. Child.45, 506–519 (1933)
Licznerski, G., Lindsten, J.: Trisomy 21 in man due to maternal non-disjunction during the first meiotic division. Hereditas (Lund)70, 153–154 (1972)
Mutton, D. E.: Origin of the trisomic 21 chromosome. Lancet1973 I, 375
Penrose, L. S.: Relative effects of paternal and maternal age in mongolism. J. Genet.27, 219–227 (1933)
Robinson, J. A.: Origin of extra chromosome in trisomy 21. Lancet1973 I, 131–133
Sasaki, M., Hara, Y.: Paternal origin of the extra chromosome in Down's syndrome. Lancet1973 II, 1257–1258
Schnedl, W.: Unterschiedliche Fluoreszenz der beiden homologen Chromosomen Nr. 3 beim Menschen. Humangenetik12, 59–63 (1971)
Schnedl, W.: Analysis of the human karyotype by the recent banding techniques. Arch. Genet.46, 65–98 (1973)
Uchida, I. A.: Paternal origin of the extra chromosome in Down's syndrome. Lancet1973 II, 1258
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Wagenbichler, P., Killian, W., Rett, A. et al. Origin of the extra chromosome No. 21 in Down's syndrome. Hum Genet 32, 13–16 (1976). https://doi.org/10.1007/BF00569971
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00569971