Summary
The bioavailability of digoxin in three tablets prepared from materials with different particle sizes was measured in healthy volunteers in a cross-over study using an alcoholic solution of digoxin as a reference standard. Its bioavailability in tablets with particle sizes of 7 µ or 13 µ was 78–97% of that of digoxin in solution. The tablet with largest particle size (102 µ) showed markedly lower bioavailability than the reference solution, namely 39%. It is obvious that particle size is an important determinant of the dissolution rate and bioavailability of digoxin.
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Jounela, A.J., Pentikäinen, P.J. & Sothmann, A. Effect of particle size on the bioavailability of digoxin. Eur J Clin Pharmacol 8, 365–370 (1975). https://doi.org/10.1007/BF00562664
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DOI: https://doi.org/10.1007/BF00562664