Summary
Propranolol, a beta-adrenoceptor blocking drug, was administered to 6 healthy pregnant volunteers between 32 and 36 weeks gestation and when at least 6 weeks postparum. On both occasions, subjects were given propranolol 120 mg orally or 10 mg intravenously in randomised order with a minimum washout period of 1 week. Propranolol was assayed in plasma by gas-liquid chromatography with electron-capture detection and the pharmacokinetic parameters were investigated. There were no significant alterations in elimination half-life, clearance or apparent volume of distribution per kilogram antenatally compared with postnatally: bioavailability was also unchanged. It is concluded that the disposition of propranolol is not altered during pregnancy.
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Evans GH, Nies AS, Shand DG (1973) The disposition of propranolol. III. Decreased half-life and volume of distribution as a result of plasma binding in man, monkey, dog and rat. J Pharmacol Exp Ther 186: 114–122
Fiddler GI (1974) Propranolol and pregnancy (Letter). Lancet 2: 722–723
Fidler J, Smith V, Fayers P, De Swiet M (1983) Randomised controlled comparative study of methyldopa and oxprenolol in treatment of hypertension in pregnancy. Br Med J 286: 1927–1930
Joelsson I, Barton MD (1969) The effect of blockade of the beta receptors of the sympathetic nervous system of the fetus. Acta Obstet Gynecol Scand 48 [Suppl 3]: 75–79
Kinney CD (1981) Determination of metoprolol in plasma and urine by gas-liquid chromatography with electron-capture detection. J Chromatogr 225: 213–218
Lewis PJ, De Swiet M, Chamberlain GVP, Bulpitt CJ (1977) The management of hypertension in the pregnant woman. In: Lewis PJ (ed) Therapeutic problems in pregnancy. Lancaster, MTP Press Ltd, p 53–62
Lieberman BA, Stirrat, GM, Cohen SL, Beard RW, Pinker GD (1978) The possible adverse effect of propranolol on the fetus in pregnancies complicated by severe hypertension. Br J Obstet Gynaecol 85: 678–683
Munnell EW, Taylor HC (1947) Liver blood flow in pregnancy — hepatic vein catheterisation. J Clin Invest 26: 952–956
O'Hare MF, Leahey W, Murnaghan GA, McDevitt DG (1983) Pharmacokinetics of sotalol during pregnancy. Eur J Clin Pharmacol 24: 521–524
Pruyn SC, Phelan JP, Buchanan GC (1979) Long-term propranolol therapy in pregnancy; maternal and fetal outcome. Am J Obstet Gynecol 135: 485–489
Reed RL, Cheney CB, Fearon RE, Hook R, Hehre FW (1974) Propranolol therapy throughout pregnancy: a case report. Anaesth Analg 53: 214–218
Rubin PC, Butters L, Clark DM, Reynolds B, Sumner DJ, Steedman D, Low RA, Reid JL (1983) Placebo-controlled trial of atenolol in treatment of pregnancy-associated hypertension. Lancet 1: 431–434
Shand DG (1976) Pharmacokinetics of propranolol: a review: Postgrad Med J 52 [Suppl 4] 22–25
Shand DG, Nuckolls EM, Oates JA (1970) Plasma propranolol levels in adults with observations in four children. Clin Pharmacol Ther 11: 112–120
Shand DG, Evans GH, Nies AS (1971) The almost complete hepatic extraction of propranolol during intravenous administration in the dog. Life Sci 10: 1417–1421
Smith MT, Livingstone I, Eadie MJ, Hooper WD, Triggs EJ (1983a) Metabolism of propranolol in the human maternal-placental-foetal unit. Europ J Clin Pharmacol 24: 727–732
Smith MT, Livingstone I, Eadie MJ, Hooper WD, Triggs EJ (1983b) Chronic propranolol administration during pregnancy. Maternal pharmacokinetics. Europ J Clin Pharmacol 25: 481–490
Tindall VR (1975) The liver in pregnancy. Clin Obstet Gynaecol 2: 441–462
Van Petten GR, Willes RF (1970)β-Adrenoceptive responses in the unanaesthetised ovine fetus. Br J Pharmacol 38: 572–582
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O'Hare, M.F., Kinney, C.D., Murnaghan, G.A. et al. Pharmacokinetics of propranolol during pregnancy. Eur J Clin Pharmacol 27, 583–587 (1984). https://doi.org/10.1007/BF00556896
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DOI: https://doi.org/10.1007/BF00556896