Summary
The acute effects of a single dose of diltiazem (Tildiem®), a calcium antagonist, were studied in 9 patients with severely impaired renal function (GFR between 0.03 and 0.87 ml/s/1.73 m2). Control measurements were made of inulin and PAH clearance, creatinine, blood pressure, heart rate and ECG. Following administration of diltiazem 120 mg, 7 blood samples were collected in the first 12 h and after 24 h, 32 h, 48 h; urine was collected for the first 12 h, 12–24 h and 24–48 h, and blood pressure, heart rate and ECG were recorded after 6 h. Diltiazem and its main metabolite, desacetyldiltiazem, had a pharmacokinetic profile similar to that in patients with normal renal function (peak plasma concentration, half-life and urinary excretion). Diltiazem is normally eliminated in the urine to a small extent, because it is metabolized, and this also applies to desacetyldiltiazem, which is probably further metabolized.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Cavero I, Boudot JP, Lefevre-Borg F, Roach AG (1978) Pharmalogical evaluation of diltiazem and its desacetyled metabolite in several animal species. In: Bing RJ (ed) New drug therapy with a calcium antagonist, Diltiazem Hakone Symposium 1978. Excerpta Medica, Amsterdam Princeton, pp 61–80
Grolleau R, Puech P, Renevier A (1979) Traitement du syndrome de Prinzmetal par le diltiazem. Arch Mal Cœur 72: [9] 1044–1045
Guermonprez JL, Blanchard D, Lancelin B, Isorni Ph, Maurice P (1980) Evaluation of diltiazem in stable angina by serial exercise tests. Circulation 62 [Suppl 3]: Abstract 1137
Rovei V, Mitchard M, Morselli PL (1977) Simple, sensitive and specific gas chromatographic method for the quantification of diltiazem in human body fluids. J Chromatogr 138: 391–398
Morselli PL, Rovei V, Mitchard M, Durand A, Gomeni R, Larribaud J (1978) Pharmacokinetics and metabolism of diltiazem in man (observations on healthy volunteers and angina pectoris patients). In: Bing RJ (ed) New drug therapy with calcium antagonist. Diltiazem Hakone Symposium 1978. Excerpta Medica, Amsterdam Princeton
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Pozet, N., Brazier, J.L., Aïssa, A.H. et al. Pharmacokinetics of diltiazem in severe renal failure. Eur J Clin Pharmacol 24, 635–638 (1983). https://doi.org/10.1007/BF00542213
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00542213