Summary
Neurofilament immunoreactive nerve fibers were demonstrated in human skin using indirect immunohistochemical technique with antibodies to neurofilament polypeptides. Neurofilament-positive fibers were seen as free nerve endings in the epidermis and in dermal papilla, in Meissner's corpuscles and as fibers crousing in the dermis. Strongly fluorescent nerve fibers were also seen around hair follicles, sweat gland ducts and sometimes in relation to blood vessels. From the distribution pattern it was concluded that predominantly sensory nerve fibers were labelled and that this technique may be used to study reinnervation of cutaneous sensory nerved following tramatic injuries and surgical procedures.
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Dalsgaard, C.I., Björklund, H., Jonsson, C.E. et al. Distribution of neurofilament-immunoreactive nerve fibers in human skin. Histochemistry 81, 111–114 (1984). https://doi.org/10.1007/BF00490102
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DOI: https://doi.org/10.1007/BF00490102