Abstract
Evidence for cow's milk allergy was looked for prospectively in 15 children with recurrent vomiting. Whereas radiological examination showed gastro-oesophageal reflux to be present in all patients, 3 out of 15 children presented an enteropathy associated with an increased number of IgE plasmocytes in small intestinal biopsy tissue. These three patients did not improve with conventional medical therapy but a striking improvement occurred within 24 h on a cow's milk-free diet. We conclude that diagnostic confusion between gastrooesophageal reflux and cow's milk allergy can occur and that the presence of IgE plasmocytes in small intestinal biopsy tissue indicates IgE-mediated cow's milk protein allergy. All cases of “intractable” gastro-oesophageal reflux should be suspected of cow's milk allergy and investigated acrodingly.
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Abbreviations
- GER:
-
gastro-oesophageal reflux
References
Byrne WJ (1981) “Antral dysmotility” unrecognized cause of chronic vomiting during infancy. Ann Surg 193:521–524
Carre IJ (1959) The natural history of the partial thoracic stomach (hiatal hernia) in children. Arch Dis Child 34:344–347
Forget PP, Meradji M (1976) Contribution of fibreoptic endoscopy to diagnosis and management of children with gastrooesophageal reflux. Arch Dis Child 51:60–66
Freier S, Kletter B (1970) Milk allergy in infants and young children. Current knowledge. Clin Pediatr (Phila) 9:449–454
Gerrard JW, Mackenzie JWA, Goluboff N, Garson JZ, Maningas CS (1973) Cow's milk allergy: prevalence and manifestation is an unselected series of newborns. Acta Paediatr Scand [Suppl] 234:1–21
Kuitunen P, Visakorpi JK, Savilahti E, Pelkonen P (1975) Malabsorption syndrome with cow's milk intolerance: clinical findings and course in the light of 54 cases. Arch Dis Child 50:351–356
Mepham BL, Frater W, Mitchel B (1979) The use of proteolytic enzymes to improve Ig staining by the PAP technique. Histochem J 11:345–351
Rosekrans PCM, Meijer CJLM, Cornelisse CJ, Van der Wal AM, Lindeman J (1980) Use of morphometry and immunohistochemistry of smallintestinal biopsy specimens in the diagnosis of food allergy. J Clin Pathol 33:125–130
Savilahti E (1973) Immunochemical study of the malabsorption syndrome with cow's milk intolerance. Gut 14:491–501
Shiner M, Ballard J, Smith ME (1975) The small intestinal mucosa in cow's milk allergy. Lancet 1:136–140
Shiner M, Brook CGD, Ballard J, Herman S (1975) Intestinal biopsy in the diagnosis of cow's milk protein intolerance without acute symptoms. Lancet 2:1061–1063
Sternberger LA (1974) Immunocytochemistry. Prentia Hall Inc., Englewood Cliffs NJ
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Forget, P., Arends, J.W. Cow's milk protein allergy and gastro-oesophageal reflux. Eur J Pediatr 144, 298–300 (1985). https://doi.org/10.1007/BF00441767
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DOI: https://doi.org/10.1007/BF00441767