Abstract
Protracted diarrhoea (PD) in infancy is a common presenting symptom of severe combined immunodeficiency (SCID), but the pathophysiological mechanisms are usually unexplained. An infant is presented with fatal SCID in whom PD was associated with multiple viral excretion from the intestinal tract and the presence of large PAS-positive macrophages at the villous tips of the jejunum. The possibility of immunodeficiency should be considered in all infants with PD and viruses may play an important role in the pathogenesis of some cases of PD occurring in infants with immunodeficiency.
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Larcher VF, Shepherd R, Francis DEM, Harries JT (1977) Protracted diarrhoea in infancy; analysis of 82 cases with particular reference to diagnosis and management. Arch Dis Child 52:597–605
Banatvala JE (1979) The role of viruses in acute diarrhoeal disease. Clin Gastroeterol (No. 3) 8:569–598
Saulsbury FT, Winkelstein JA, Yolken RH (1980) Chronic rota-virus infection in immunodeficiency. J Pediatr 97:61–65
Katz AJ, Rosen FS (1977) Gastrointestinal complications of immunodeficiency syndromes. In Immunology of the Gut. Ciba Foundation Symposium, (new series) 46:243–261
Horowitz S, Lorenzsonn VW, Olsen WA, Albrecht R, Hong R (1974) Small intestinal disease in T cell deficiency. J Pediatr 85: 457–462
Ament, ME, Ochs HD, Davis SD (1973) Structure and function of the gastrointestinal tract in primary immunodeficiency syndromes; a study of 39 patients. Medicine (Baltimore) 52:227–248
Ament ME, Ochs HD (1973) Gastrointestinal manifestations of chronic granulamatous disease. N Engl J Med 288:382–387
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Booth, I.W., Chrystie, I.L., Levinsky, R.J. et al. Protracted diarrhoea, immunodeficiency and viruses. Eur J Pediatr 138, 271–272 (1982). https://doi.org/10.1007/BF00441216
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DOI: https://doi.org/10.1007/BF00441216