Abstract
The specific high-affinity binding of 3H-imipramine to rat brain membranes was investigated. Five weeks of lithium treatment decreased the number of binding sites, but had no effect on the affinity constants. Long-term imipramine treatment had no effect on the number of binding sites but apparently decreased the affinity. The latter effect was probably due to imipramine remaining in the membrane preparation.
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Plenge, P., Mellerup, E.T. 3H-imipramine high-affinity binding sites in rat brain. Effects of imipramine and lithium. Psychopharmacology 77, 94–97 (1982). https://doi.org/10.1007/BF00436105
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DOI: https://doi.org/10.1007/BF00436105