Abstract
The effects of ethanol (0.4, 0.8, 1.6, and 2.4 g/kg p.o.) on behavior of aggressive, timid, and sociable male mice treated with the drug on paired interactions with non-aggressive males given water were investigated. Under control interactions, aggressive mice attacked their partners, timid mice showed defensive-escape activities though their partners were completely non-aggressive, and sociable mice intensively investigated their partners. A low dose of ethanol (0.4 g/kg) increased while higher doses (0.8 to 2.4 g/kg) reduced aggressive activities in aggressive mice. Ethanol (0.8 g/kg) also evoked aggressive behavior in non-aggressive timid mice but no dose of ethanol stimulated aggression in non-aggressive sociable mice. Ethanol altered timid defensive-escape activities only in the highest dose of 2.4 g/kg: this dose increased defences and escapes in aggressive males while it reduced defensive upright postures in timid mice. However, 2.4 g/kg of ethanol reduced also another upright movement (exploratory rearing) in timid mice. Sociable activities were not increased by any dose of ethanol tested. By contrast, 0.4 g/kg of ethanol reduced sniffing and following partners in sociable mice. Thus, ethanol exhibited relatively strong aggression-stimulating effects in aversively disposed subjects while the drug was not able to supress timid defensive escape behavior and to stimulate active non-aggressive contacts between strange male mice.
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Borgesová, M., Kadlecová, O., Kršiak, M.: Behaviour of untreated mice towards alcohol- or chlordiazepoxide-treated partners. Activ. nerv. sup. (Praha) 13, 206–207 (1971)
Cairns, R. B., Scholz, S. D.: Fighting in mice: dyadic escalation and what is learned. J. comp. physiol. Psychol. 85, 540–550 (1973)
Cappell, H., Herman, C. P.: Alcohol and tension reduction. Quart. J. Stud. Alcohol 33, 33–64 (1972)
Cappell, H., Latané, B.: Effects of alcohol and caffeine on the social and emotional behaviour of the rat. Quart. J. Stud. Alcohol 30, 345–356 (1969)
Chamove, A. S., Harlow, H. F.: Exaggeration of self-aggression following alcohol ingestion in rhesus monkey. J. abnorm. Psychol. 75, 207–209 (1970)
Chance, M. R. A., Mackntosh, J. H., Dixon, A. K.: The effects of ethyl alcohol on social encounters between mice. J. Alcoholism (Lond.) 8, 90–93 (1973)
Cressman, R. J., Cadell, T. E.: Drinking and the social behaviour of rhesus monkey. Quart. J. Stud. Alcohol 32, 764–774 (1971)
Crowley, T. J., Stynes, A. J., Hydinger, M., Kaufman, I. C.: Ethanol, methamphetamine, pentobarbital, morphine and monkey social behaviour. Arch. gen. Psychiat. 31, 829–838 (1974)
Cutler, M. G., Mackintosh, J. H., Chance, M. R. A.: Effects of the environment on the behavioural response of mice to nonataxic doses of ethyl alcohol. Neuropharmacology 14, 841–846 (1975)
Grant, E. C., Mackintosh, J. H.: A comparison of the social postures of some common laboratory rodents. Behavior 21, 246–259 (1963)
Kamback, M. C.: The hippocampus and motivation: A re-examination. J. gen. Psychol. 89, 313–324 (1973)
Kršiak, M.: Behavioural changes and aggressivity evoked by drugs in mice. Res. Comm. chem. Path. Pharmacol. 7, 237–257 (1974)
Kršiak, M.: Timid singly-housed mice: their value in prediction of psychotropic activity of drugs. Brit. J. Pharmacol. 35, 141–150 (1975)
Kršiak, M., Borgesová, M.: Drugs and spontaneous behaviour: why are detailed studies still so rare? Activ. nerv. sup. (Praha) 14, 285–293 (1972)
Kršiak, M., Borgesová, M.: Effect of alcohol on behaviour of pairs of rats. Psychopharmacologia (Berl.) 32, 201–209 (1973)
Kršiak, M., Steinberg, H.: Psychopharmacological aspects of aggression: a review of the literature and some new experiments. J. Psychosomat. Res. 13, 243–252 (1969)
Lorenz, K.: On aggression. London: Methuen 1966
McDonald, A. L., Heimstra, N. W.: Social influence on the response to drugs. V. Modification of behaviour of non-drugged rats by drugged. Psychopharmacologia (Berl.) 8, 174–180 (1965)
Miczek, K. A.: Intraspecies aggression in rats: Effects of d-amphetamine and chlordiazepoxide. Psychopharmacologia (Berl.) 39, 275–301 (1974)
Miczek, K. A., Barry, H., III: Pharmacology of sex and aggression. In: Behavioral pharmacology, S. D. Glick and J. Goldfarb, eds. St. Louis: Mosby (in press, 1976)
Miczek, K. A., Barry, H., III: Effects of alcohol on attack and defensive-submissive reactions in rats. Psychopharmacologia (Berl.) (in press)
Peeke, H. V. S., Ellman, G. E., Herz, M. J.: Dose dependent alcohol effects on the aggressive behavior of the convict cichlid (Cichlasoma nigrofasciatum). Behav. Biol. 8, 115–122 (1973)
Poole, T. B.: Some studies on the influence of chlordiazepoxide on the social interaction of golden hamsters. Brit. J. Pharmacol. 48, 538–545 (1973)
Siegel, S.: Nonparametric statistics. New York: McGraw-Hill 1956
Silverman, A. P.: The social behaviour of laboratory rats and the action of chlorpromazine and other drugs. Behaviour 27, 1–38 (1966a)
Silverman, A. P.: Barbiturates, lysergic acid diethylamide, and the social behaviour of laboratory rats. Psychopharmacologia (Berl.) 10, 155–171 (1966b)
Tamimie, H. S.: Response of alcohol treated cocks to day-old and one-week old chicks. Poult. Sci. 47, 1366–1367 (1968)
Tikal, K., Benešová, O.: The effect of some psychotropic drugs on contact behavior in a group of rats. Activ. nerv. sup. (Praha) 14, 168–169 (1972)
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Kršiak, M. Effect of ethanol on aggression and timidity in mice. Psychopharmacology 51, 75–80 (1976). https://doi.org/10.1007/BF00426325
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DOI: https://doi.org/10.1007/BF00426325