Summary
The influence of increased central venous pressure (CVP) on the plasma concentration of arginine vasopressin (pAVP) was examined in 7 healthy males subjected to water immersion (WI) up to the neck following overnight food- and fluid restriction. During WI the subject sat upright in a pool (water temperature=35.0‡ C) for 6 h. In control experiments the subject assumed the same position outside the pool wearing a water perfused garment (water temperature=34.6‡ C). CVP increased markedly during WI and after 20 min of immersion it attained a level which was significantly higher than the control value (10.9±1.5 (mean ± SE) vs. 2.2±1.3 mm Hg, p<0.01). This increase was sustained throughout the 6 h WI period. Simultaneously, after 20 min pAVP during WI was significantly lower than control values (1.8±0.3 vs. 2.2±0.3 pg·ml−1, p<0.05) and sustained throughout WI. Systolic arterial pressure increased significantly by 7–10 mm Hg (p<0.05) after 2 h of WI, while diastolic arterial pressure was unchanged. Heart rate was decreased by 10 bpm throughout immersion. There was no change in plasma osmolality when comparing control with immersion. A pronounced osmotic diuresis, natriuresis and kaliuresis occurred during WI, counteracting an acute significant increase in plasma volume of 6.5±1.9% (P<0.01 within 20 min of immersion). We conclude that an increase in CVP due to WI is accompanied by suppressed pAVP.
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This investigation was supported by the Danish Space Board, grant nr. 1112-32/83, 1112-33/83 and 1112-19/84
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Norsk, P., Bonde-Petersen, F. & Warberg, J. Central venous pressure and plasma arginine vasopressin during water immersion in man. Europ. J. Appl. Physiol. 54, 71–78 (1985). https://doi.org/10.1007/BF00426302
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DOI: https://doi.org/10.1007/BF00426302