Summary
Two hundred and four men with impaired glucose tolerance (borderline diabetes) discovered in a screening examination have been observed for five years and repeated tests of glucose tolerance performed. By pre-determined criteria 27 men ‘worsened to diabetes’ and this metabolic deterioration was not significantly influenced by treatment with carbohydrate restriction with or without a daily dose of 50 mg phenformin. Of the baseline variables measured prior to treatment allocation only the blood glucose values were significantly predictive of ultimate worsening to diabetes.
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Jarrett, R.J., Keen, H., Fuller, J.H. et al. Worsening to diabetes in men with impaired glucose tolerance (“borderline diabetes”). Diabetologia 16, 25–30 (1979). https://doi.org/10.1007/BF00423146
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DOI: https://doi.org/10.1007/BF00423146