Abstract
Lumbar CSF 5 HIAA and HVA were measured following probenecid administration in acute psychotic patients before and during treatment with phenothiazines. Patients with more classical schizophrenic symptoms had higher values for 5 HIAA/HVA than other psychotics, depressives, and inmate volunteers. Prior to treatment CSF 5 HIAA, but not HVA, correlated significantly with several clinical items related to psychotic disorganization. Phenothiazine treatment produced significant increases in CSF HVA which could not be correlated with the dose of antipsychotic or antiparkinson drugs.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Aghajanian, G. K.: Influence of drugs on the firing of serotonin-containing neurons in brain. Fed. Proc. 31, 91–96 (1972).
Anden, N.-E., Roos, B.-E., Werdinius, B.: Effects of chlorpromazine, haloperidol, and reserpine on the levels of phenolic acids in rabbit corpus striatum. Life Sci. 3, 149–158 (1964).
Bowers, M. B., Jr.: Clinical measurements of central dopamine and 5-hydroxytryptamine metabolism: reliability and interpretation of CSF acid monoamine metabolite measures. Neuropharmacol. 23, 26–33 (1972a).
Bowers, M. B., Jr.: CSF 5-HIAA and HVA following probenecid in unipolar depressives treated with amitriptyline. Psychopharmacologia (Berl.) 23, 26–33 (1972b).
Bowers, M. B., Jr.: Acute Psychosis induced by psychotomimetic drug abuse II. Neurochemical Findings. Arch. gen. Psychiat. 27, 440–442 (1972).
Bowers, M. B., Jr., Heninger, G. R., Gerbode, F. A.: CSF 5-HIAA and HVA in psychiatric patients. Int. J. Neuropharmacol.. 8, 255–262 (1969).
Bowers, M. B., Jr., Roth, R. H.: Interaction of atropine-like drugs with dopaminecontaining neurons in rat brain. Brit. J. Pharmacol. 44, 301–306 (1972).
Bruno, A., Allegranza, A.: The effect of haloperidol on the urinary excretion of dopamine, homovanillic, and vanilmandelic acids in schizophrenics. Psychopharmacologia (Berl.) 8, 60–66 (1965).
Chase, T. N., Schnur, J. A., Gordon, E. K.: CSF monoamine catabolites in drug-induced extrapyramidal disorders. Neuropharmacol. 9, 265–268 (1970).
Gerbode, F. A., Bowers, M. B., Jr.: Measurement of acid monoamine metabolites in human and animal CSF. J. Neurochem. 15, 1053–1055 (1968).
Korf, J., Van Praag, H. M.: Amine metabolism in the human brain: further evaluation of the probenecid test. Brain Res. 35, 221–230 (1971).
Kupfer, D. J., Detre, T. P., Foster, F. G., Tucker, G. J., Delgado, J.: The application of Delgado's telemetric mobility recorder for human studies. Behav. Biol. 7, 585–590 (1972).
Mellor, C. S.: The first rank symptoms of schizophrenia. Brit. J. Psychiat. 117, 15–23 (1970).
Moir, A. T. B., Ashcroft, G. W., Crawford, T. B. B., Eccleston, D., Guldberg, H. C.: Cerebral metabolites in CSF as a biochemical approach to the brain. Brain 93, 357–368 (1970).
O'Keefe, R., Sharman, D. F., Vogt, M.: Effect of drugs used in psychoses on cerebral dopamine metabolism. Brit. J. Pharmacol. 38, 287–304 (1970).
Persson, T., Roos, B.-E.: Acid metabolites from monoamines in CSF of chronic schizophrenics. Brit. J. Psychiat. 115, 95–98 (1969).
Rimon, R., Roos, R.-E., Rakkolainen, V., Alanen, Y.: The content of 5-HIAA and HVA in the CSF of patients with acute schizophrenia. J. Psychosom. Res. 15, 375–378 (1971).
Robins, E., Guze, S. B.: Establishment of diagnostic validity in psychiatric illness: its application to schizophrenia. Amer. J. Psychiat. 126, 983–987 (1970).
Stephens, J. H., Astrup, C., Mangrum, J. C.: Prognostic factors in recovered and deteriorated schizophrenics. Amer. J. Psychiat. 122, 1116–1120 (1966).
Tamarkin, N. R., Goodwin, F. K., Axelrod, J.: Rapid elevation of biogenic amine metabolites in human CSF following probenecid. Life Sci. 9, 1397–1408 (1970).
Taylor, M. A.: Schneiderian first rank symptoms and clinical prognostic features in schizophrenia. Arch. gen. Psychiat. 26, 64–67 (1972).
Van Praag, H. M., Korf, J.: Retarded depression and the dopamine metabolism. Psychopharmacologia (Berl.) 19, 199–203 (1971).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bowers, M.B. 5-Hydroxyindoleacetic acid (5 HIAA) and homovanillic acid (HVA) following probenecid in acute psychotic patients treated with phenothiazines. Psychopharmacologia 28, 309–318 (1973). https://doi.org/10.1007/BF00422751
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00422751