Summary
Glomerular filtration rate (GFR), renal plasma flow (RPF) and roentgenographic kidney size were measured in six newly diagnosed male diabetics with a mean age of 25 years. Glomerular filtration rate was elevated before treatment to the same extent as found previously. A significant fall in both kidney size and glomerular filtration rate was found after treatment with insulin for 3 months. These results support further the concept that there is a basal connection between enlarged kidneys and the elevated GFR of early diabetes.
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Mogensen, C.E., Andersen, M.J.F. Increased kidney size and glomerular filtration rate in untreated juvenile diabetes: Normalization by insulin-treatment. Diabetologia 11, 221–224 (1975). https://doi.org/10.1007/BF00422325
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DOI: https://doi.org/10.1007/BF00422325