Abstract
Antipsychotic drugs have been found to markedly stimulate prolactin secretion in male and female rats. The amount of prolactin released was greater in females than in males. Most non-antipsychotic phenothiazines failed to alter prolactin. These results imply that the dopamine receptor that inhibits prolactin release may be similar to the dopamine receptor involved in the action of antipsychotic drugs.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Clemens, J. A., Gallo, R. V., Whitmoyer, D. I., Sawyer, C. H.: Prolactin-responsive neurons in the rabbit hypothalamus. Brain Res. 25, 371–379 (1971)
Cook, L., Kelleher, R.: Drug effects on the behavior of animals. Ann. N.Y. Acad. Sci. 96, 315–335 (1962)
Dickerman, S., Clark, J., Dickerman, E., Meites, J.: Effects of Haloperidol on serum and pituitary prolactin and on hypothalamic PIF in rats. Neuroendocrinology 9, 332–340 (1972)
Donovan, J.: Radiation sickness and its control with thiethylperazine (“Torecan”): A preliminary evaluation. Med. J. Australia 1, 614–615 (1963)
Frantz, A. G.: The regulation of prolactin secretion in humans. In: Frontiers in neuroendocrinology. W. F. Ganong and L. Martini, eds., pp. 337–374. New York: Oxford University Press 1973
Fuxe, K., Hokfelt, T.: Central monoaminergic systems and hypothalamic function. In: The hypothalamus. L. Martini, M. Motta and F. Fraschini, eds., pp. 123–138. New York: Academic Press 1970
Horn, A. S., Synder, S. H.: Chlorpromazine and dopamine: Conformational similarities that correlate with the antischizophrenic activity of phenothiazine drugs. Proc. nat. Acad. Sci. (Wash.) 68, 2325–2328 (1971)
Janssen, P., Niemegeers, C., Schellekens, K., Lenaerts, F.: Is it possible to predict the clinical effects of neuroleptic drugs (major tranquillizers) from animal data? Arzneimittel-Forsch. 17, 841–854 (1967)
Lu, K. H., Amenomori, Y., Chen, C. L., Meites, J.: Effects of central acting drugs on serum and pituitary prolactin levels in rats. Endocrinology 87, 667–672 (1970)
Lu, K. H., Meites, J.: Inhibition by l-Dopa and monoamine oxidase inhibitors of pituitary prolactin release: stimulation by methldopa and d-amphetamine. Proc. Soc. exp. Biol. (N.Y.) 137, 480–483 (1971)
Macleod, R. M., Lehmeyer, J. E.: Studies on the mechanism of dopamine-mediated inhibition of prolactin secretion. Endocrinology 94, 1077–1084 (1974)
Matthysse, S.: Dopamine and the pharmacology of schizophrenia. State of the evidence. J. psychiat. Res. 11, in press (1974)
Meites, J., Clemens, J.: Hypothalamic control of prolactin secretion. Vitam. and Horm. 30, 165–221 (1972)
Smalstig, E. B., Clemens, J. A.: Inhibition of serum prolactin by apomorphine in chlorpromazine treated and lactating rats. Fed. Proc. 32, 308 (1973)
Smalstig, E. B., Sawyer, B. D. Clemens, J. A.: Inhibition of rat prolactin release by apomorphine. Endocrinology 95, 123–129 (1974)
Timberlake, W. H., Schwab, R.: Experimental preparation W-483 in the treatment of Parkinson's disease. New Engl. J. Med. 247, 98–100 (1952)
VanderBrook, M., Olson, K., Richmond, M., Kuizenga, M.: Pharmacology of a new antihistamine, Β-pyrrolidine-ethyl-phenothiazine (pyrrolazote). J. Pharmacol. exp. Ther. 94, 197–208 (1948)
Weikel, J., Wheeler, A., Joiner, P.: Metabolic fate and toxicology of methdilazine (10-(l-methyl-3-pyrrolidylmethyl)phenothiazine]. Toxicol. appl. Pharmacol. 2, 68–82 (1960)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Clemens, J.A., Smalstig, E.B. & Sawyer, B.D. Antipsychotic drugs stimulate prolactin release. Psychopharmacologia 40, 123–127 (1974). https://doi.org/10.1007/BF00421361
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00421361