Abstract
This study examined the effects on smooth-pursuit eye tracking of single doses of CPZ (0.667 and 1.334 mg/kg), diazepam (0.071, 0.142, and 0.284 mg/kg), and secobarbital (100 mg). Only the barbiturate significantly affected the ability to follow a moving target with smooth-pursuit eye movements. In repeated testing of a single subject, 130 mg of secobarbital disrupted smooth-pursuit movements at least until 24 hrs after ingestion.
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This study was supported in part by grant MH-19477, USPHS, and USFDA contract No. 72-42. Dr. Holzman is the recipient of Research Scientist Award No. K5-MH-70900, USPHS. We express our thanks to Dr. Alfred Heller for helpful comment.
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Holzman, P.S., Levy, D.L., Uhlenhuth, E.H. et al. Smooth-pursuit eye movements, and diazepam, CPZ, and secobarbital. Psychopharmacologia 44, 111–115 (1975). https://doi.org/10.1007/BF00420996
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DOI: https://doi.org/10.1007/BF00420996