Summary
Eleven human optic nerves from subjects in different decades ranging from the fifth to the ninth were investigated with the silver carbonate method to establish the pattern and frequency of age changes within the optic nerve head and their relationship with the glaucomatous excavation. It has been found that despite the occurrence of age degeneration at the same level of the cribriform lamina, there are definite anatomical differences as compared with glaucoma changes, especially regarding the distribution of axonal damage.
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Agduhr, E.: Einige Beiträge zur Ag.-Technik der Stückimpregnierung der Nerven. Anat. Anz. 69, 363–376 (1930)
Anderson, D.R., Braverman, S.: Reevaluation of the optic disc vasculature. Amer. J. Ophth. 82 (2), 165–174 (1976)
Cajal, S.R.: Degeneration and regeneration of the nervous system. Vol. II. p. 583–596, New York: Hafner, 1959
Goder, G.: Die Veränderungen der Kapillarisation des Optikus und ihre pathogenetische Bedeutung. Angiologica, 3, 59–75 (1966)
Hollwich, F.: Senile Exkavation, In: Der Augenarzt, Vol. V. p. 755, Leipzig: Thieme, 1963
Jabonero, V.: Eine neue Technik zur Färbung peripherer nervöser Elemente. Z. mikr. anat. Forsch. 59, 562–582 (1953)
Levy, N.S.: Functional implication of axoplasmic transport. Invest. Ophth. 13 (9), 639–640 (1974a)
Levy, N.S.: The effects of elevated intraocular pressure on slow axonal protein flow. Invest. Ophth. 13 (9), 691–695 (1974b)
Minckler, D.S., Tso, M.O.M.: A light microscopic, autoradiographic study of axoplasmic transport in the normal rhesus optic nerve head. Amer. J. Ophth. 82, 1–15 (1976a)
Minckler, D.S., McLean, I.W., Tso, M.O.M.: Distribution of axonal and glial elements in the rhesus optic nerve head studied by electron microscopy. Amer. J. Ophth. 82, 179 179–187 (1976b)
Sachsenweger, R.: Altern und Auge. Ein Hdb. der Gerontologie und Geriatrie des menschlichen Sehorgans. pp. 263–271, Leipzig: Thieme 1971
Vrabec, Fr.: Spherical swelling of retinal axons in the aged. Brit. J. Ophth. 49, 113–119 (1965a)
Vrabec, Fr.: On the development and senile changes of the innervation of the trabecular meshwork in man. Structure of the Eye, II. Symposium. pp. 215–222, Stuttgart: Schattauer 1965b
Vrabec, Fr.: The temporal raphé of the human retina. Amer. J. Ophth. 62, 926–938 (1966)
Vrabec, Fr.: Age changes of the inner surface of the trabecular meshwork shown by the replica technique. Invest. Ophthalm. 13 (12), 950–953 (1974)
Vrabec, Fr.: Glaucomatous cupping of the human optic disk. A. v. Graef. Arch. klin. exp. Ophthal. 198, 223–234 (1976)
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Vrabec, F. Age changes of the human optic nerve head. Albrecht von Graefes Arch. Klin. Ophthalmol. 202, 231–236 (1977). https://doi.org/10.1007/BF00407873
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DOI: https://doi.org/10.1007/BF00407873