Summary
Experimental solitary ellipsoid liver tumors in the rat can be induced by inoculation of a tumor-cell suspension of known potency into the liver parenchyma. During laparotomy, the largest (a) and the smallest (b) superficial diameters of the tumor were measured on the surface of the liver with vernier calipers. Four different formulas have been tested and compared with the actual volume from the extirpated tumor and tumor weight. Within the size range of 15–700 mm3, based on the calculation of the difference between logarithmic tumor volume from the different formulas versus logarithmic volume of extirpated and dissected tumors and regression analyses, volume of the unremoved liver tumor can be best calculated according to the formula V=a x b 2/2.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Begg AC (1971) Kinetic and histological changes of serially transplanted mouse tumor. Cell Tissue Kinet 4:401–411
Boyse EA, Old LJ, Thomas G (1962) A report on some observations with a simplified cytotoxic test. Transplant Bull 29:63–67
Brues AM, Weiner AE, Andervont HB (1939) Relation between latent period and growth rate in chemically induced tumors. Proc Soc Exp Biol Med 42:374–377
Chambers H, Scott GM (1930) Variations in the growth of the Jensen rat sarcoma and the influence of technique. J Pathol Bacteriol 33:553–561
Dethlefsen LA, Prewitt JMS, Mendelsohn ML (1968) Analysis of tumor growth curves. J Natl Cancer Inst 40:389–405
Fisher ER, Fisher B (1959a) Experimental studies of factors influencing hepatic metastases. I. The effect of number of tumor cells injected and time of growth. Cancer 12:926–928
Fisher B, Fisher ER (1959b) Experimental studies of factors influencing hepatic metastases. III. Effect of surgical trauma with special reference to liver injury. Ann Surg 150:731–744
Fisher B, Fisher ER (1959c) Experimental evidence in support of the dormant tumor cell. Science 130:918–919
Fisher B, Fisher ER, Lee SH (1961) Effects of alteration of liver blood flow upon experimental hepatic metastases. Surg Gynecol Obstet 112:11–18
Fisher B, Fisher ER (1961a) Experimental studies of factors influencing hepatic metastases. IV. Effect of nutrition. Cancer 14:547–554
Fisher B, Fisher ER (1961b) Experimental studies of factors influencing hepatic metastases. VIII. Effect of anticoagulants. Surgery 50:240–247
Fisher ER, Fisher B (1961c) Experimental studies of factors influencing hepatic metastases. VII. Effect of reticuloendothelial interference. Cancer Res 21:275–281
Fisher ER, Fisher B (1962) Experimental studies of factors influencing hepatic metastases. X. Reticuloendothelial stimulation. Cancer Res 22:478–483
Fisher B, Fisher ER (1963) Experimental studies of factors influencing hepatic metastases. XII. Effect of increased arterial blood flow. Proc Soc Exp Biol Med 112:126–128
Hermens AF, Barendsen GW (1967) Cellular proliferation patterns in an experimental rhabdomyosarcoma in the rat. Eur J Cancer 3:361–369
Kopper L, Steel GG (1975) The therapeutic response of three human tumor lines maintained in immune-suppressed mice. Cancer Res 35:2704–2713
Lala PK (1971) Studies on tumor cell population kinetics. In: Busch H (ed) Methods in cancer research, vol 6. Academic Press, New York, pp 3–95
McCredie JA, Inch WR, Kruuv J, Watson TA (1965) The rate of tumor growth in animals. Growth 29:331–347
Marsh MC (1933) On an ambivalent effect of a single acute trauma on the growth of transplanted mouse tumors. Am J Cancer 17:735–742
Mayneord WV (1932) On a law of growth of Jensen's rat sarcoma. Am J Cancer 16:841–846
Moore JV, Dixon B (1977) Serial transplantation, histology and cellular kinetics of a rat adenocarcinoma. Cell Tissue Kinet 10:583–590
Mottram JC (1935) On the origin of tar tumours in mice, whether from single cells or many cells. J Pathol Bacteriol 40:407–414
Nilsson LAV, Zettergren L (1967) Effect of hepatic artery ligation on induced primary liver carcinoma in rats. Acta Pathol Microbiol Scand 71:187–193
Schrek R (1935) A quantitative study of the growth of the Walker rat tumor and the Flexner-Jobling rat carcinoma. Am J Cancer 24:807–822
Simpson-Herren L, Lloyd HH (1970) Kinetic parameters and growth curves for experimental tumor systems. Cancer Chemother Rep 54:143–174
Steel GG, Adams K, Barrett JC (1966) Analysis of the cell population kinetics of transplanted tumours of widely-differing growth rate. Br J Cancer 20:784–800
Steele G Jr, Sjögren HO (1974) Cross-reacting tumor-associated antigen(s) among chemically induced rat colon carcinomas. Cancer Res 34:1801–1807
Willis RA (1968) Pathology of tumours, 4th edn. Butterworth, London
Author information
Authors and Affiliations
Additional information
Supported by grants from the Swedish Cancer Society, grant no 98-B80-15XA, John and Augusta Persson's Foundation for Cancer Research, Segerfalk's Foundation, the Medical Faculty of the University of Lund
Rights and permissions
About this article
Cite this article
Carlsson, G., Gullberg, B. & Hafström, L. Estimation of liver tumor volume using different formulas—An experimental study in rats. J Cancer Res Clin Oncol 105, 20–23 (1983). https://doi.org/10.1007/BF00391826
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00391826