Abstract
In a previous ultrastructural study, the benefit of a single high dose of vitamin D3 on fracture healing in a healthy animal model was demonstrated. This study examined the biomechanical consequences of applying a single high dose of vitamin D3 in a healthy rabbit model subsequent to femoral fracture. The fracture load, the values of energy absorbed until fracture and the flexural rigidity values of the vitamin D group were significantly higher than the corresponding ones of the control group in the case of fracture. On the other hand, for intact bones, those values did not differ significantly between the two groups. It was concluded that single high-dose vitamin D3 application had positive effects on fracture healing in a healthy animal model, as far as the parameters related to mechanical strength are concerned.
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References
Akkuş O (1995) Biomechanical evaluation of fracture healing in long bones; an experimental study on intramedullary stabilized rabbit tibia. MS Thesis, Middle East Technical University, Ankara
Akkuş O, Korkusuz F, Akkaş N (1995) Monitoring fracture healing using vibration analysis. In: Ege R (ed) Abstract book of SICOT Regional and XIV, Turkish National Congress of Orthopaedic Surgery and Traumatology, September 29 – October 4, 1995, Izmir, Turkey, Bizim Büro Basimevi, Ankara, p 281
Alkalay D, Shany S, Dekel S (1989) Serum and bone vitamin D metabolites in elective patients and patients after fracture. J Bone Joint Surg [Br] 71:85–87
Beresford JN, Gallagher JA, Russell RGG (1986) 1,25-dihydroxyvitamin D3 and human bone-derived cells in vitro: effects on alkaline phosphatase, type I collagen and proliferation. Endocrinology 119:1776–1785
Brand RA, Rubin CT (1990) Fracture healing. In: Evarts CMcC (ed) Surgery of the musculoskeletal system. Churchill Livingstone, New York, pp93–114
Brumbaugh PF, Speer DP, Pitt MJ (1982) 1α,25-Dihydroxyvitamin D3; a metabolite of vitamin D that promotes bone repair. Am J Pathol 106:171–179
Buckwalter JA, Cruess RL (1991) Healing of the musculoskeletal tissues. In: Rockwood Jr CA, Green DP, Bucholz RW (eds) Rockwood and Green's fractures in adults. JB Lippincott, New York, pp 181–222
Buekwalter JA, Glimcher MJ, Cooper RR, Recker R (1995) Bone biology. Part I. Structure, blood supply, cells, matrix and mineralization. J Bone Joint Surg [Am] 77:1256–1275
Buckwalter JA, Glimcher MJ, Cooper RR, Recker R (1995) Bone biology. Part II. Formation, form, modeling, remodeling and regulation of cell function. J Bone Joint Surg [Am] 77:1276–1289
Canalis E (1985) Effect of growth factors on bone cell replication and differentiation. Clin Orthop 193:246–263
Dekel S, Salama R, Edelstein S (1983) The effect of vitamin D and its metabolites on fracture healing in chicks. Clin Sci 65:429–436
DeLuca HF, Krisinger J, Darwish H (1990) The vitamin D system: 1990. Kidney Int 38[Suppl 29]:S2–S8
Ege R (1989) Traumatology fractures and joint injuries (in Turkish). Kadioĝlu Matbaasi, Ankara
Eventov I, Frisch B, Alk D, Eisenberg Z, Weisman Y (1989) Bone biopsies and serum vitamin-D levels in patients with hip fracture. Acta Orthop Scand 60:411–413
Finkelman RD, Butler WT (1985) Vitamin D and skeletal tissues. J Oral Pathol 14:191–215
Frost HM (1989) The biology of fracture healing; an overview for clinicians. Part I. Clin Orthop 248:283–293
Frost HM (1989) The biology of fracture healing; an overview for clinicians. Part II. Clin Orthop 248:294–309
Gallagher JA, Beneton M, Harvey L, Lawson DEM (1986) Response of rachitic rat bones to 1,25-dihydroxyvitamin D3: biphasic effects on mineralization and lack of effect on bone resorption. Endocrinology 119:1603–1609
Hulth A (1989) Current concepts of fracture healing. Clin Orthop 249:265–284
Lidor C, Dekel S, Edelstein S (1987) The metabolism of vitamin D3 during fracture healing in chicks. Endocrinology 120:389–393
Lidor C, Dekel S, Hallel T, Edelstein S (1987) Levels of active metabolites oF vitamin D3 in the callus of fracture repair in chicks. J Bone Joint Surg [Br] 69:132–136
Lindgren JU, Narechania RG, McBeath AA, Lange TA, DeLuca HF (1981) Effects of 1,25 dihydroxyvitamin D3 and calcitonin on fracture healing in adult rats. Clin Orthop 160:304–308
Meller Y, Kestenbaum RS, Shany S, Zuili I, Yankowitz N, Giat J, Konforti A, Torok G (1984) Parathyroid hormone, calcitonin and vitamin D metabolites during normal fracture healing in humans; a preliminary report. Clin Orthop 183:238–245
Meller Y, Kestenbaum RS, Shany S, Galinsky D, Zuili I, Yankovitch N, Giat J, Conforti A, Torok G (1985) Parathormone, calcitonin and vitamin D metabolites during normal fracture healing in geriatric patients. Clin Orthop 199:272–279
Ömeroĝlu S, Ömeroĝlu H, Erdoĝan D (1995) The effect of vitamin D3 on fracture healing in healthy guinea pigs; a histopathological study. In: Ege R (ed) Abstract book of SICOT Regional and XIV Turkish National Congress of Orthopaedic Surgery and Traumatology, September 29–October 4, 1995, Izmir, Turkey. Bizim Büro Basimevi, Ankara, p422
Ömeroĝlu S, Erdoĝan D, Ömeroĝlu H (1996) Effects of single high dose vitamin D3 on fracture healing; an ultrastructural study in healthy guinea pigs. Arch Orthop Trauma Surg 116:37–40
Raisz LG, Kream B (1983) Regulation of bone formation. First of two parts. N Engl J Med 309:29–35
Simmons DJ (1985) Fracture healing perspectives. Clin Orthop 200:100–113
Stern PH (1990) Vitamin D and bone. Kidney Int 38[Suppl 29]:S17–S21
Triffitt JT (1987) Initiation and enhancement of bone formation; a review. Acta Orthop Scand 58:673–684
Turner CH, Burr DB (1993) Basic biomechanical measurements of bone: a tutorial. Bone 14:595–608
Walters MR (1992) Newly identified actions of the vitamin D endocrine system. Endocr Rev 13:719–764
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Ömeroĝlu, H., Ates, Y., Akkuş, O. et al. Biomechanical analysis of the effects of single high-dose vitamin D3 on fracture healing in a healthy rabbit model. Arch Orthop Trauma Surg 116, 271–274 (1997). https://doi.org/10.1007/BF00390051
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DOI: https://doi.org/10.1007/BF00390051