Summary
This is a case report of a tumour which showed all the histological features of fibrous dysplasia without any features of high-grade malignancy, yet had become locally aggressive, causing cortical erosion and extension into soft tissue. Fibrous dysplasia is a well-recognised enitity that encompasses monostotic lesions, polyostotic involvement and Albright's syndrome [6, 8]. Lesions in bone usually spare the epiphysis before puberty, but often involve the epiphyseal area after maturity and can progress during adult life [3]. Unless cystic [6, 10] or malignant change [7, 10, 11] occurs, fibrous dysplasia usually remains contained within bone.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Campanacci M (1976) Osseofibrous dysplasia of long bones, a new clinical entity. Ital J Orthop Traumatol 2:221–237
Dahlin DC, Bertoni F, Beabout JW, Campanacci M (1984) Fibrocartilaginous mesenchymoma with low-grade malignancy. Skeletal Radiol 12:263–269
Harris WH, Dudley HR, Barry RJ (1962) The natural history of fibrous dysplasia. J Bone Joint Surg [Am] 44:207–233
Kempson RL (1966) Ossifying fibroma of the long bones. A light and microscopy study. Arch Pathol 82:218–233
Kurt A-M, Unni KK, McLoad RA, Pritchard DJ (1990) Lowgrade intrasosseous osteosarcoma. Cancer 65:1418–1428
Lichtenstein L, Jaffe HL (1942) Fibrous dysplasia of bone: a condition affecting one, several or many bones, the graver cases of which may present abnormal pigmentation of skin, premature sexual development, hyperthyroidism or still other extra-skeletal abnormalities. Arch Pathol 33:777–816
Mirra JM (1989) Bone tumours: clinical, radiologic, and pathologic correlations. Lee & Febiger, Philadelphia, pp 248–384
Schajowicz F (1985) Tumours and tumour-like lesions of bone and joints. Springer, New York Berlin Heidelberg, pp 478–488
Schwartz DT, Alpert M (1964) The malignant transformation of fibrous dysplasia. Am J Med Sci 247:1–20
Simpson AHR, Creasy TS, Williamson DM, Wilson DJ, Spivey JS (1989) Cystic degeneration of fibrous dysplasia masquerading as sarcoma. J Bone Joint Surg [Br] 71:434–436
Yabut SM, Kenan S, Sissons HA, Lewis MM (1988) Malignant transformation of fibrous dysplasia. Clin Orthop 228:281–288
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Latham, P.D., Athanasouz, N.A. & Woods, C.G. Fibrous dysplasia with locally aggressive malignant change. Arch Orthop Trauma Surg 111, 183–186 (1992). https://doi.org/10.1007/BF00388097
Issue Date:
DOI: https://doi.org/10.1007/BF00388097