Abstract
This report presents evidence that the molluscan neuropeptide FMRFamide can directly activate a ligand-gated ion channel in Helix neurones. Using the patch-clamp technique we have observed unitary currents activated by the application of FMRFamide onto outside-out patches. As for the whole-cell response, Na+ ions are the main charge carriers. We conclude that FMRFamide may act as a fast depolarising neurotransmitter in the Helix nervous system.
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Cottrell, G.A., Green, K.A. & Davies, N.W. The neuropeptide Phe-Met-Arg-Phe-NH2 (FMRFamide) can activate a ligand-gated ion channel in Helix neurons. Pflügers Arch. 416, 612–614 (1990). https://doi.org/10.1007/BF00382698
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DOI: https://doi.org/10.1007/BF00382698