Abstract
The effects of the flavonoid quercetin on cell proliferation and voltage-dependent K+ current were studied on mouse neuroblastoma×glioma hybrid cells. In the presence of 1 % fetal calf serum, quercetin inhibited both cell proliferation and K+ current with effective doses inducing half-maximum effects of 10 μM and 70 μM respectively. Valinomycin (1 nM) antagonized 80 % of the growth-inhibitory effects of 10 μM quercetin. The results suggest that at least a part of the antiproliferative effect of quercetin is mediated by a K+ channel blockade. They further confirm a role for K+ channels in mitogenesis and cell proliferation.
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Rouzaire-Dubois, B., Gérard, V. & Dubois, J.M. Involvement of K+ channels in the quercetin-induced inhibition of neuroblastoma cell growth. Pflugers Arch. 423, 202–205 (1993). https://doi.org/10.1007/BF00374395
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DOI: https://doi.org/10.1007/BF00374395