Abstract
Human anti-centromere sera from scleroderma patients were used to detect centromere antigens of mouse fibroblast cells. An Mr=59000 centromere protein was localized exclusively on mitotic chromosomes. The association of this protein with the mitotic chromosomes proved to be DNase I sensitive. In interphase nuclei, this centromere antigen was not detectable by immunoblot techniques. The results suggest that the Mr=59000 mitosis specific protein may be necessary for the structural stability of kinetochores during mitosis.
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Hadlaczky, G., Praznovszky, T., Rasko, I. et al. Centromere proteins. Chromosoma 97, 282–288 (1989). https://doi.org/10.1007/BF00371967
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DOI: https://doi.org/10.1007/BF00371967