Abstract
Seventy-five episodes of clinically relevant anaerobic bacterial bacteremia observed in cancer patients were reviewed. Gastrointestinal (22.7%), hematological (22.7%) and female genital tract (18.6%) cancers were the most common underlying malignant diseases. Among 84 strains of strict anaerobic bacteria recovered in the 75 patients, gram-negative rods were isolated in 49 patients (58.3%), gram-positive rods in 29 patients (34.5%) and gram-positive cocci in 6 patients (8%). Bacteroides spp. and Clostridium spp. were the most frequent pathogens (85.7%). Twenty-one episodes of bacteremia were polymicrobial, aerobic gram-positive cocci being the most frequently associated pathogens. When identified, the primary sites were the gastrointestinal tract (40%), the female genital tract (17.3%), skin and soft tissue (14.6%), the oropharynx (12%) and the lower respiratory tract (6.7%). The source remained unknown in 7 cases (9.3%). The overall survival (evaluated 10 days after the occurrence of bacteremia) was 82.5%. There was no difference in mortality between patients with monomicrobial and polymicrobial bacteremia. Pulmonary complications were more frequent in patients with fatal outcome in comparison to patients who survived. The mortality rate of the patients adequately treated was 10.3% compared to 41% for the patients not treated or treated inadequately (P=0.016, X2).
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Bartlett JG (1989) Anaerobic bacteria: general concepts. In: Mandell GL, Douglas RG, Bennett JE (eds) Principles and practice of infectious diseases, 3rd edn. Churchill Livingstone New York, pp 1828–1842
Bouza E, Reig M, Garcia de la Tone M, Rodriguez-Creixerus M, Romero J, Cercenado E, Baquero F (1985) Retrospective analysis of two hundred and twelve cases of bacteremia due to anaerobic microorganisms. Eur J Clin Microbiol 4:262–267
Brook I (1989) Anaerobic bacterial bacteremia: 12 years experience in two military hospitals. J Infect Dis 160:1071–1075
Caya JG, Farmer SG, Ritch PS, Wollenberg NJ, Tieu TM, Oechler NW, Spivey M (1986) Clostridial septicemia complicating the course of leukemia. Cancer 57:2045–2048
Condon RE (1984) Bacteroides bacteremia. Arch Surg 119:897–898
Cooper GS, Haulin DS, Shlaes DM, Salata RA (1990) Polymicrobial bacteremia in the late 1980s: predictors of outcome and review of the literature. Medicine 69: 114–123
Coullioud D, Van der Auwera P, Viot M, Lasset C, CEMIC (French-Belgian Study Club of Infectious Diseases in Cancer) (1993) Prospective multicentric study of the etiology of 1051 bacteremic episodes in 782 cancer patients. Support Care Cancer 1:34–46
EORTC International Antimicrobial Therapy Cooperative Group (1988) Empiric antimicrobial therapy for febrile granulocytopenic cancer patients: lessons from EORTC trials. Eur J Cancer Clin Oncol 24:S35-S45
Fainstein V, Elting LS, Bodey GP (1987) Bacteremia caused by non-sporulating anaerobes in cancer patients. Medicine 68:151–156
Finegold SM (1990) Anaerobes: problems and controversies in bacteriology, infections, and suspectibility testing. Rev Infect Dis 12:S223-S230
Kagnoff MF, Armstrong D, Blevins A (1972) Bacteroides bacteremia. Experience in a hospital for neoplastic diseases. Cancer 29:245–251
Lagast H, Meunier F, Klastersky J (1982) Moxalactam treatment of anaerobic infections in cancer patients. Antimicrob Agents Chemother 22:604–610
Lombardi DP, Engleberg NC (1992) Anaerobic bacteremia: incidence, patient characteristics, and clinical significance. Am J Med 92:53–60
Mathias RG, Harding GK, Gorwith MJ, Stiver HG, Sigurdson E, Gratton CA, Ronal AR (1977) Bacteremia due to bacteroidaceae: a review of 92 cases. J Infect Dis 135:S69-S73
Meunier F (1989) Infections in patients with acute leukemia and lymphoma. In: Mandell G, Douglas RG, Bennett J (eds) Principles and practice of infectious disease, 3rd edn. Churchill Livingstone, New York, pp 2265–2275
Reuben JG, Musher DM, Hamill RJ, Broucke I (1989) Polymicrobial bacteremia: clinical and microbiological patterns. Rev Infect Dis 11: 161–183
Sinkovics JG, Smith J (1970) Septicemia with Bacteroides in patients with malignant diseases. Cancer 25:663–671
Styrt B, Gorbach SL (1989) Recent development in the understanding of the pathogenesis and treatment of anaerobic infections (first of two parts). N Engl J Med 320:240–246
Thaler M, Gill V, Pizzo P (1986) Emergence of Clostridium tertium as pathogen in neutropenic patients. Am J Med 81:596–600
Vazquez F, Mendez FJ, Perez F, Mendoza MC (1987) Anaerobic bacteremia in a General Hospital: retrospective five-year analysis. Rev Infect Dis 9:1038–1043
Weinstein MP, Reller LB (1984) Clinical importance of “breakthrough” bacteremia. Am J Med 76:175–180
Wynne JW, Armstrong D (1972) Clostridial septicemia. Cancer 29:215–221
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Noriega, L.M., Van der Auwera, P., Phan, M. et al. Anaerobic bacteremia in a cancer center. Support Care Cancer 1, 250–255 (1993). https://doi.org/10.1007/BF00366044
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DOI: https://doi.org/10.1007/BF00366044