Abstract
4-Dimethylaminophenol hydrochloride (DMAP), 20 mg/kg i.V., was found to oxidize in rats as much as 50% of the hemoglobin to ferrihemoglobin but did not cause kidney lesions. 4-Aminophenol hydrochloride, 400mg/kg i.V., oxidized only 25% of the hemoglobin and produced large tubular necroses. In highly toxic doses only, e.g., twice the LD50, DMAP also produced tubular necroses.
Zusammenfassung
4-Dimethylaminophenolhydrochlorid (DMAP) 20 mg/kg i.V., oxidierte in Ratten 50% des Hämoglobins zu Ferrihämoglobin, verursachte aber in dieser Dosis keine Nierenschäden.4-Aminophenolhydrochlorid, 400 mg/kg i.V., oxidierte nur 25% des Hämoglobin, bewirkte aber ausgedehnte Nekrosen der Nierentubuli. Nur in höchst toxischen Dosen, etwa der zweifachen LD50, bewirkte auch DMAP Nekrosen der Tubuli.
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Abbreviations
- DMAP:
-
4-Dimethylaminophenol hydrochloride
- AP:
-
4-Aminophenol hydrochloride
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Kiese, M., Szinicz, L., Thiel, N. et al. Ferrihemoglobin and kidney lesions in rats produced by 4-aminophenol or 4-dimethylaminophenol. Arch. Toxicol. 34, 337–340 (1975). https://doi.org/10.1007/BF00353854
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DOI: https://doi.org/10.1007/BF00353854