Abstract
Out of a series of 900 biopsy-proven cases of skeletal “fibroxanthoma” (nonossifying fibroma, fibrous cortical defect), we studied 72 patients with more than one lesion. Age, sex, coexistent conditions such as neurofibromatosis, and histologic and radiographic appearance of the lesions were evaluated. Multiple skeletal fibroxanthomas are probably more common than previously suspected. (At least 8% of the 900 patients in our archives had multiple lesions). Only a small percentage (5%) of patients with multiple skeletal fibroxanthomas had coexistent neurofibromatosis. These lesions are histologically indistinguishable from their solitary counterparts and most commonly present in the lower extremities. Four radiographic patterns were noted: (1) clustered lesions-usually about the knee. (2) nonclustered lesions-in opposite ends of long bones. (3) coalescent lesions-several lesions coalescing over time. This observation has not been previously reported. (4) emergent lesions-lesions appearing in previously unaffected bone. Familiarity with these features may obviate biopsy.
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Evans GA, Park WM (1978) Familial multiple non-osteogenic fibromata J Bone Joint Surg [Br] 60:416
Holt JF, Wright EM (1948) The radiologic features of neurofibromatosis. Radiology 51:647
Holt JF (1978) Neurofibromatosis in children. AJR 130: 615
Hunt JC, Pugh DG (1961) Skeletal lesions in neurofibromatosis. Radiology 76:1
Klatte EC, Franken EA, Smith JA (1976) The radiographic spectrum in neurofibromatosis. Semin Roentgenol 11:17
Mandell GA, Dalinka MK, Coleman BG (1979) Fibrous lesions in the lower extremities in neurofibromatosis. AJR 133:1135
Meszaros WT, Guzzo F, Schorsch H (1966) Neurofibromatosis. AJR 98:557
Pitt MJ, Mosher JF, Edeiken MD (1972) Abnormal periosteum and bone in neurofibromatosis. Radiology 103: 143
Schwartz AM, Ramos RM (1980) Neurofibromatosis and multiple nonossifying fibroma. AJR 135:617
Wilner D (1982) Radiology of bone tumors and allied disorders. WB Saunders, Philadelphia, p 551
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The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense.
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Moser, R.P., Sweet, D.E., Haseman, D.B. et al. Multiple skeletal fibroxanthomas: radiologic-pathologic correlation of 72 cases. Skeletal Radiol 16, 353–359 (1987). https://doi.org/10.1007/BF00350960
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DOI: https://doi.org/10.1007/BF00350960