Summary
The acute phase response to injury includes metabolic alterations, such as fever, leucocytosis, enhanced uptake of some metals and amino acids by liver, and changes in the synthesis of certain plasma proteins. Many of these effects can be elicited either in vivo or in tissue culture by monocyte- and keratinocyte-derived cytokine interleukin 1 (IL-1), which had earlier been variably termed leucocytic endogenous mediator, lymphocyte activating factor, or endogenous pyrogen. Although recombinant murine IL-1 was shown to induce hepatic synthesis of acute phase proteins other authors demonstrated that hepatocyte stimulating factor (HSF) is distinct from IL-1. Possible relationships between HSF und IL-1 and the molecular mechanisms of action of these cytokines on the synthesis of acute phase proteins are briefly discussed.
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Andersen MM (1983) Leucocyte-associated plasma proteins. Scand J Clin Lab Invest 43: 49–59
Auron PE, Webb AC, Rosenwasser LJ, Mucci SF, Rich A, Wolff SM, Dinarello CA (1984) Nucleotide sequence of human monocyte interleukin 1 precursor cDNA. Proc Natl Acad Sci USA 81: 7907–7911
Bauer J, Birmelin M, Northoff GH, Northemann W, Tran-Thi TA, Ueberberg H, Decker K, Heinrich PC (1984) Induction of rat α2-macroglobulin in vivo and in hepatocyte primary cultures: synergistic action of glucocorticoids and a Kuppfer cell-derived factor. FEBS Lett 177: 89–94
Bauer J, Weber W, Tran-Thi TA, Northoff GH, Decker K, Gerok W, Heinrich PC (1985) Murine interleukin 1 stimulates α2-macroglobulin synthesis in rat hepatocyte primary cultures (in preparation)
Baumann H, Firestone GL, Burgess TL, Gross KW, Yamamoto KR, Held WA (1983) Dexamethasone regulation of α1-acid glycoprotein and other acute phase reactants in rat liver and hepatoma cells. J Biol Chem 258: 563–570
Baumann H, Jahreis GP, Sauder DN, Koj A (1984) Human keratinocytes and monocytes release factors which regulate synthesis of major acute phase plasma proteins in hepatic cells from man, rat and mouse. J Biol Chem 259: 7331–7342
Baumann H, Sauder DN, Jahreis GP (1985) Structurally different hepatocyte stimulating factors of human keratinocytes regulate a uniform set of major acute phase plasma proteins in rat hepatocytes. J Cell Biol (submitted for publication)
Budek W, Bünning P, Heinrich PC (1984) Rat lung tissue is a site of α1-proteinase inhibitor synthesis: evidence by cell-free translation. Biochem Biophys Res Comm 122: 394–400
Colten HR (1982) Biosynthesis of MHC-linked complement proteins (C2, C4 and factor B) by mononuclear phagocytes. Molec Immunol 19: 1279–1285
Dinarello CA (1984) Interleukin 1. Rev. Inf Diseas 6: 51–95
Dinarello CA, Clowes GHA Jr, Gordon AH, Saravis CA, Wolff SM (1984) Cleavage of human interleukin 1: isolation of a peptide fragment from plasma of febrile humans and activated monocytes. J Immunol 133: 1332–1338
Fouad FM, Scherer R, Abd-el-Fattah M, Ruhenstroth-Bauer G (1980) Biosynthesis of plasma proteins in serum-free medium by primary monolayer culture of rat hepatocytes. Eur J Cell Biol 21: 175–179
Gahring L, Baltz ML, Peppys MB, Daynes R (1984) Effect of ultraviolet radiation on production of epidermal cell thymocyte activating factor/interleukin 1 in vivo and in vitro. Proc Natl Acad Sci USA 81: 1198–1201
Gillis S, Mizel SB (1981) T-cell lymphoma model for the analysis of interleukin 1 mediated T-cell activation. Proc Natl Acad Sci USA 78: 1133–1137
Gordon AH, Koj A (eds) (1985) The Acute Phase Response. Role of Interleukin 1 and Other Mediators. Elsevier, North Holland, Biomedical Press, Amsterdam, New York, Oxford
Gross V, Andus T, Tran-Thi TA, Bauer J, Decker K, Heinrich PC (1984) Induction of acutephase proteins by dexamethasone in rat hepatocyte primary cultures. Exp Cell Res 151: 46–54
Hanson DF, Murphy PA, Windle BE (1980) Failure of rabbit neutrophils to secrete endogenous pyrogen when stimulated with staphylococci. J Exp Med 151: 1360–1371
Kampschmidt RF (1981) Leucocytic endogenous mediator/endogenous pyrogen. In: Powanda MC, Canonico PG (eds) Infection: The Physiologic and Metabolic Responses of the Host. Elsevier/North Holland Biomedical Press, pp 56 – 74
Kampschmidt RF, Upchurch HF, Worthington ML III (1983) Further comparisons of endogenous pyrogens and leucocytic endogenous mediators. Infection Immun 41: 6–10
Karin M, Haslinger A, Holtgreve H, Richards I, Krauter P, Westphal H, Beato M (1984) Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene. Nature 308: 513–519
Koj A (1974) Acute-phase reactants — their synthesis, turnover and biological significance. In: Allison AC (eds) Structure and Function of Plasma Proteins, vol 1. Plenum Press, London and New York, pp 73–131
Koj A, Gauldie J, Regoeczi E, Sauder DN, Sweeney GD (1984) The acute-phase response of cultured rat hepatocytes. System characterization and the effect of human cytokines. Biochem J 224: 505–514
Koj A, Gauldie J, Sweeney GD, Regoeczi E, Sauder DN (1985) A simple bioassay for monocyte-derived hepatocyte stimulating factor: increased synthesis of α2-macroglobulin and reduced synthesis of albumin by cultured rat hepatocytes. J Immunol Meth 76: 317–328
Lomedico PT, Gubler U, Hellmann CP, Dukovich M, Giri JG, Pan YCE, Collier K, Semionow R, Chua AO, Mizel SB (1984) Cloning and expression of murine interleukin 1 cDNA in Escherichia coli. Nature 312: 458–461
McAdam KPWJ, Li J, Knowles J, Foss NT, Dinarello CA, Rosenwasser LJ, Selinger MJ, Kaplan MM, Goodman R (1982) The biology of SAA: identification of the innducer, in vitro synthesis, and heterogeneity determined with monoclonal antibodies. Ann N Y Acad Sci 389: 126–136
Mizel SB, Mizel D (1981) Purification to apparent homogeneity of murine interleukin 1. J Immunol 126: 834–837
Murphy PA, Cebula TA, Levin J, Windle BE (1981) Rabbit macrophages secrete two biochemically and immunologically distinct endogenous pyrogens. Infection Immun 34: 177–183
Northemann W, Andus T, Gross V, Nagashima M, Schreiber G, Heinrich PC (1983) Messenger RNA activities of four acute phase proteins during inflammation. FEBS Lett 161: 319–322
Oppenheim JJ, Gery I (1982) Interleukin 1 is more than an interleukin. Immunology Today 3: 113–119
Princen JMG, Nieuwenhuizen W, Mol-Backx GPBM, Yap SH (1981) Direct evidence of transcriptional control of fibrinogen and albumin synthesis in rat liver during the acute phase response. Biochem Biophys Res Comm 102: 717–723
Ramadori G, Sipe JD, Dinarello CA, Mizel SB, Colten HR (1985) Pretranslational modulation of acute phase hepatic protein synthesis by murine recombinant interleukin 1 (IL-1) and purified human IL-1. J Exp Med (in press)
Ricca GA, Hamilton RW, McLean JW, Conn A, Kalinyak JE, Taylor JM (1981) Rat α1-acid glycoprotein mRNA cloning of double-stranded cDNA and kinetics of induction of mRNA levels following acute inflammation. J Biol Chem 256: 10362–10368
Ritchie DG, Fuller GM (1981) An in vitro bioassay for leucocyte endogenous mediator(s) using cultured rat hepatocytes. Inflammation 5: 275–287
Ritchie DG, Fuller GM (1983) Hepatocyte stimulating factor: a monocyte-derived acutephase regulatory protein. Ann N Y Acad Sci 408: 498–502
Rogers J, Kalsheker N, Wallis S, Speer A, Coutelle CH, Woods D, Humphries SE (1983) The isolation of clone for human α1-antitrypsin and the detection of α1-antitrypsin mRNA from liver and leucocytes. Biochem Biophys Res Comm 116: 375–382
Sanders KD, Fuller GM (1983) Kupffer cell regulation of fibrinogen synthesis in hepatocytes. Thromb Res 32: 133–145
Sauder DN, Carter CS, Katz SI, Oppenheim JJ (1982) Epidermal cell production of thymocyte-activating factor (ETAF). J Invest Dermatol 79: 34–39
Sauder DN, Monessa NL, Katz SI, Dinarello CA, Gallin JI (1984) Chemotactic cytokine: the role of leukocytic pyrogen and epidermal cell thymocyte-activating factor in neutrophil chemotaxis. J Immunol 132: 828–832
Schultz D, Macintyre S, Chelladurai M, Kushner I (1982) The role of prostaglandins in the C-reactive protein response. Ann N Y Acad Sci 389: 465–466
Sztein MB, Vogel SN, Sipe JD, Murphy PA, Mizel SB, Oppenheim JJ, Rosenstreich DL (1981) The role of macrophages in the acute phase response: SAA inducer is closely related to lymphocyte activating factor and endogenous pyrogen. Cell Immunol 63: 164–176
Tatsuta E, Sipe JD, Shirahama T, Skinner M, Cohen AS (1983) Different regulatory mechanism for serum amyloid A and serum amyloid P synthesis by cultured mouse hepatocytes. J Biol Chem 258: 5414–5418
Wannemacher RW Jr, Pekarek RS, Thompson WL, Curnow RT, Beall FA, Zenser TV, de Rubertis FR, Beisel WR (1975) A protein from polymorphonuclear leukocytes (LEM) which affects the rate of hepatic amino acid transport and synthesis of acute-phase globulins. Endocrinology 96: 651–661
Wolowski BMRNJ, Fuller GM (1985) Identification and partial characterization of hepatocyte-stimulating factor from leukemia cell lines: comparison with interleukin 1. Proc Natl Acad Sci USA 82: 1443–1447
Wood DD, Bayne EK, Goldring MB, Gowen M, Hamerman D, Humas JL, Ihrie EJ, Lipsky PE, Staruch MJ (1985) The four biochemically distinct species of human interleukin 1 all exhibit similar biological activities. J Immunol 134: 895–903
Yonehara S, Yonehara-Takahashi M, Ishii A, Nagata S (1983) Different binding of human interferon α1 and α2 to common receptors on human and bovine cells. J Biol Chem 258: 9046–9049
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Koj, A. Cytokines regulating acute inflammation and synthesis of acute phase proteins. Blut 51, 267–274 (1985). https://doi.org/10.1007/BF00320521
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DOI: https://doi.org/10.1007/BF00320521
Key words
- Cytokines
- Interleukin 1
- Interleukin 2
- Lymphocyte activating factor
- Endogenous pyrogen
- Hepatocyte stimulating factor
- Prostaglandins
- Stimulated macrophages
- Acute phase proteins
- Fibrinogen
- Haptoglobin
- α1-acid glycoprotein
- α2-macroglobulin
- C-reactive protein
- Serum amyloid A
- Albumin
- mRNA transcription
- Eukaryotic gene expression