Summary
A blind study showing that serum from patients with Alzheimer's disease causes immunolysis of mammalian brain synaptosomes is reported. Control, aged-matched, sera were largely without effect. The immunolysis was directed mainly against cholinergic synaptosomes. The data presented support the hypothesis that autoimmune mechanisms may operate in the pathogenesis of Alzheimer's disease.
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Foley, P., Bradford, H.F., Docherty, M. et al. Evidence for the presence of antibodies to cholinergic neurons in the serum of patients with Alzheimer's disease. J Neurol 235, 466–471 (1988). https://doi.org/10.1007/BF00314249
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DOI: https://doi.org/10.1007/BF00314249