Summary
A patient with a discrete metastasis in the ventral hypothalamus and optic chiasm is reported, who developed an abnormal daily rhythm of oral temperature without alteration of the 24-h mean temperature. This region, its afferents, and its efferents appear to be important in the neural regulation of human circadian rhythmicity.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Aschoff J (ed) (1981) Biological rhythms. In: Handbook of behavioral neurobiology, vol 4. Plenum, New York
Aschoff J, Gerecke U, Wever R (1967) Desynchronization of human circadian rhythms. Jpn J Physiol 17:450–457
Case records of the Massachusetts General Hospital (1983) (Case 33-1983) A 55-year-old woman with diabetes insipidus and a suprasellar mass. N Engl J Med 309:418–425
Conroy RTWL, Mills JN (1970) Human circadian rhythms. Churchill, London
DeArmond SJ, Fusco MM, Dewey MM (1976) Structure of the human brain. Oxford University Press, New York Oxford
Dierickx K, Vandesande F (1977) Immunocytochemical localization of the vasopressinergic and the oxytocinergic neurons in the human hypothalamus. Cell Tissue Res 184:15–27
Fuller CA, Lydic R, Sulzman FM, Albers HE, Tepper B, Moore-Ede MC (1981) Circadian rhythm of body temperature persists after suprachiasmatic lesions in the squirrel monkey. Am J Physiol 241:R385-R391
Greenhouse SW, Geisser S (1959) On methods in the analysis of profile data. Psychometrika 24:95–112
Haugh RM, Markesbery WR (1983) Hypothalamic astrocytoma. Arch Neurol 40:560–563
Kleitman N (1963) Sleep and wakefulness. University of Chicago Press, Chicago
Kleitman N, Ramsaroop A (1948) Periodicity in body temperature and heart rate. Endocrinology 43:1–20
Krieger DT, Krieger HP (1966) Circadian variation of the plasma 17-hydroxycorticosteroids in central nervous system disease. J Clin Endocrinol Metab 26:929–940
Krieger DT, Krieger HP (1967) Circadian patterns of urinary electrolyte excretion in central nervous system disease. Metabolism 16:815–823
Krieger DT, Glick S, Silverberg A, Krieger HP (1968) A comparative study of endocrine tests on hypothalamic disease. Circadian periodicity of plasma 11-OHCS levels, plasma 11-OHCS and growth hormone response to insulin hypoglyemia and metapyrone responsiveness. J Clin Endocrinol Metab 28:1589–1598
Lydic R, Schoene WC, Czeisler CA, Moore-Ede MC (1980) Suprachiasmatic region of the human hypothalamus: homolog to the primate circadian pacemaker? Sleep 2:355–361
Moore RY (1983) Organization and function of a central nervous system circadian oscillator: the suprachiasmatic nucleus. Fed Proc 42:2783–2789
Moore-Ede MC, Sulzman FM, Fuller CA (1982) The clocks that time us. Harvard University Press, Cambridge, Massachusetts
Page RB, Galicich JH, Grunt JA (1973) Alteration of circadian temperature rhythm with third ventricular obstruction. J Neurosurg 38:309–319
Reinberg A, Smolensky M (1983) Chronobiology and thermoregulation. Pharmacacol Ther 22:425–464
Sadun AA, Schaechter JD, Smith LEH (1984) A retinohypothalamic pathway in man: light mediation of circadian rhythms. Brain Res 302:371–377
Samis HV Jr, Capobianco S (1978) Aging and biological rhythms. Plenum, New York
Sharp GWG (1961) Reversal of diurnal temperature rhythms in man. Nature 190:146–148
Stopa EG, King JC, Lydic R, Schoene WC (1984) Human brain contains vasopressin and vasoactive intestinal polypeptide neuronal subpopulations in the suprachiasmatic region. Brain Res 297:159–163
Wehr TA, Wirz-Justice A (1982) Circadian rhythm mechanisms in affective illness and in antidepressant drug action. Pharmacopsychiatria 15:31–39
Weitzman ED, Pollak CP (1979) Disorders of the circadian sleep-wake cycle. Med Times 107:83–94
Wever RA (1979) The circadian system of man. Results of experiments under temporal isolation. Springer-Verlag, New York Berlin Heidelberg
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Schwartz, W.J., Busis, N.A. & Tessa Hedley-Whyte, E. A discrete lesion of ventral hypothalamus and optic chiasm that disturbed the daily temperature rhythm. J Neurol 233, 1–4 (1986). https://doi.org/10.1007/BF00313981
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00313981