Summary
The Landry-Guillain-Barré syndrome (LGBS) is a demyelinating disorder of the peripheral nervous system frequently preceded by infection with common viruses. Most prevalent among these agents are herpesviruses, particularly Epstein-Barr virus (EBV) and cytomegalovirus (CMV). The specific role played by antecedent viral infection in the pathogenesis of the LGBS remains obscure. In this regard, recent studies of Marek's disease (MD) neuropathy, an avian herpesvirus-induced experimental model for the LGBS, may provide insight. The autoimmune pattern of demyelination seen in MD neuropathy is histopathologically indistinguishable from that seen in the LGBS. In this paper, a comprehensive theory is discussed regarding the pathogenetic mechanisms that may be operative in the LGBS.
Zusammenfassung
Das LGBS ist eine Myelin vernichtende Krankheit der peripherischen Nerven, der man häufig bei Infektionen mit allgemeinen Viren begegnet. Am häufigsten darunter sind Herpesviren, besonders das Epstein-Barr Virus (EBV) und Cytomegalovirus (CMV). Die spezifische Rolle einer vorhergehenden Virusinfektion in der Pathogenese von LGBS bleibt ungewiß. In dieser Beziehung mögen sich neue Studien über die Neuropathie von Mareks Krankheit (MD), eine von Vögeln getragene, durch Herpesvirus verursachte experimentelle Vorlage für die LGBS, als aufschlußreich beweisen. Die autoimmune Gestalt von Demyelination, die man in MD Neuropathie beobachtet, ist von der in der LGBS beobachteten Demyelinationsgestalt histopathologisch nicht zu unterscheiden. Diese Arbeit handelt von einer umfassenden Theorie bezüglich der pathogenetischen Mechanismen, die in der LGBS wohl operieren dürfen.
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Pepose, J.S. A theory of virus-induced demyelination in the Landry-Guillain-Barré syndrome. J Neurol 227, 93–97 (1982). https://doi.org/10.1007/BF00313775
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DOI: https://doi.org/10.1007/BF00313775