Summary
Total CSF protein and CSF/serum albumin and α2-macroglobulin ratios as indicators of a disturbed blood-brain barrier were determined in 39 cases of ischaemic cerebral infarction proved by computed tomography (CT). About 50% of the patients had a barrier disturbance, whereat the CSF serum albumin ratio was shown to be the most sensitive parameter. A disturbed blood-brain barrier was more often found in cases of large infarction, as shown by CT, and occurred most frequently in the first 2 weeks of illness. No correlation was seen between enhancement in CT and disturbance of the blood-brain barrier.
Zusammenfassung
Gesamteiweiß, Liquor/Serum Albumin-Quotient und Liquor/Serum α2-Makroglobulin-Quotient als Parameter einer gestörten Blut-Hirn-Schrankenfunktion wurden bei 39 Patienten mit computertomographisch gesicherten ischämischen Hirninfarkten bestimmt. Mehr als die Hälfte hatten eine Schrankenstörung, wobei sich der Liquor/Serum Albumin-Quotient als empfindlichster Parameter erwies. Eine Schrankenstörung war bei ausgedehnten Infarkten häufiger. Sie trat hauptsächlich in den ersten beiden Krankheitswochen auf. Ein Zusammenhang mit dem Kontrastmittel-Enhancement im CT war nicht nachweisbar.
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Hornig, C.R., Busse, O., Dorndorf, W. et al. Changes in CSF blood-brain barrier parameters in ischaemic cerebral infarction. J Neurol 229, 11–16 (1983). https://doi.org/10.1007/BF00313492
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DOI: https://doi.org/10.1007/BF00313492