Abstract
A placebo-controlled double-blind clinical trial on the effect of niaprazine on children with some common sleep disorders was carried out. Niaprazine at a daily dosage of 1 mg/kg body weight or placebo at random was administered to a selected group of 36 children (aged from 6 months to 6 years) suffering from frequent nighttime waking or inability to fall asleep. The effect of niaprazine (or placebo) on sleep disorders was studied by means of continuous home-videorecorded sleep before and after the trial. A reliable positive effect of niaprazine on the sleep disorders considered was found. No adverse side effects were observed. We conclude that niaprazine seems to reprensent an effective and safe drug for the therapy of frequent nighttime waking and inability to fall asleep.
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References
Anders TF (1978) Home-recorded sleep in two- and nine-month-old infants. J Acad Child Psychol 17: 421–432
Anders TF (1979) Night-waking in infants during the first years of life. Pediatrics 63: 860–864
Anders TF, Sostek A (1976) The use of time-lapse videorecording of sleep-wake behaviour in human infants. Psychophysiology 13: 155–158
Bax MC (1980) Sleep disturbance in the young child. BMJ 5: 1177–1179
Bax MC Hart H (1976) Health needs of preschool children. Arch Dis Child 51: 848–852
Bernal JF (1973) Nightwaking in infants during the first 14 months. Dev Med Child Neurol 15: 760–769
Besana R, Fiocchi A, De Bartolomeis L, Magno F, Donati C (1984) Comparison of niaprazine and placebo in pediatric behaviour and sleep disorders: double blind clinical trial. Curr Ther Res Clin Exp 26: 56–58
Caccia S, Fong MH, Garattini S, Notarnicola A (1985) 1-Ayl-piperazine as active metabolites of drugs with an aryl-piperazine side-chain. Biochem Pharmacol 34: 393–394
Ceccarelli M, Placidi GF, Bertieri RS (1986) Valutazione clinica della niaprazina nel trattamento dei disturbi del sonno in età pediatrica: studio clinico in doppio cieco contro placebo. Riforma Med 101: 63–67
De Paillerets F, Dugas M, Gallet JP Gallet P, Barochet Y de (1971) Etude d'un sédatif de l'enfants dans 5 services de pédiatrie. Med praticienne I: 96–98
Duchenne-Marullaz P, Rispat G, Perriere JP, Hache J, Labrid C (1971) De quelques proprietés pharmacodynamiques de la niapranzine, nouvel antihistaminique. Therapie 26: 1203–1209
Durand VM, Mindell JA (1990) Behavioral treatment of multiple childhood sleep disorders. Effect on child and family. Behav Modif 14: 37–49
Ferber R (1987) The sleepless child. In: Guilleminault C (ed) Sleep and its disorders in children. Raven Press, New York, pp 141–163
Gallet JP (1985) Etude d'un sedatif à effet hypnotique chez 50 entfants présentant un trouble du sommeil. Med Infant 4: 475–479
Hache J, Tachon J (1976) Effets psicholeptiques et action sur le taux de monoamines cérébrales chez la souris d'un antihistaminique: la niaprazine. J Pharmacol. 7: 469–478
Kaene PE, Strolin Benedetti M (1979) Niaprazine a selective brain catecholamine depletor. Neuropharmacology 18: 595–600
Kaene PE, Strolin Benedetti M, Dow J (1982) The effect of niaprazine on the turnover of 5-hydroxy-tryptamine in the rat brain. Neuropharmacology 21: 163–169
Ottaviano S, Cortesi F, Giannotti F, Innocenzi M, Guidetti V, Benedetti P (1988) II videosonnogramma domiciliare nella valutazione del sonno del bambino: esperienze e prospettive. Acta Paediatr Lat 41: 457–461
Ounsted MK, Simons CD (1978) The first born child: toddlers problems. Dev Med Child Neurol 20: 710–719
Riese ML (1987) Longitudinal assessment of temperament from birth to 2 years: a comparison of full-term and preterm infants. Infant Behav Dev 10: 347–363
Salzarulo P, Chevalier A (1983) Sleep problems in children and their relationship with early disturbances of the waking-sleeping rhythms. Sleep 6: 47–51
Simonoff EA, Stores G (1986) Controlled trial of trimeprazine tartrate for night waking. Arch Dis Child 62: 253–257
What can be done for night waking in children? (1987) Lancet II: 948–949
Zucconi M, Mondini S, Gerardi R, Petrorelli R, Donati C, Bertieri RS, Cirignotta F (1988) Niaprazine: a polysomnographic study of nocturnal sleep and daytime sleepiness in healthy volunteers. Curr Ther Res Clin Exp 44: 118–132
Zuckerman B, Stevenson S, Bailey V (1987) Sleep problems in early childhood: continuities, predictive factors, and behavioral correlates. Pediatrics 80: 664–671
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Ottaviano, S., Giannotti, F. & Cortesi, F. The effect of niaprazine on some common sleep disorders in children. Child's Nerv Syst 7, 332–335 (1991). https://doi.org/10.1007/BF00304832
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DOI: https://doi.org/10.1007/BF00304832