Abstract
Low energy electromagnetic fields (EMF) exhibit a large number of biological effects. A major issue to be determined is “What is the lowest threshold of detection in which cells can respond to an EMF?” In these studies we demonstrate that a low-amplitude combined magnetic field (CMF) which induces a maximum potential gradient of 10-5 V/m is capable of increasing net calcium flux in human osteoblast-like cells. The increase in net calcium flux was frequency dependent, with a peak in the 15.3–16.3 Hz range with an apparent bandwidth of approximately 1 Hz. A model that characterizes the thermal noise limit indicates that nonspherical cell shape, resonant type dynamics, and signal averaging may all play a role in the transduction of lowamplitude EMF effects in biological systems.
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Fitzsimmons, R.J., Ryaby, J.T., Magee, F.P. et al. Combined magnetic fields increased net calcium flux in bone cells. Calcif Tissue Int 55, 376–380 (1994). https://doi.org/10.1007/BF00299318
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DOI: https://doi.org/10.1007/BF00299318