Abstract
Increasing numbers of cases of malignant tumours occurring in enterocystoplasties are being reported. Material from five cases of adenocarcinoma arising in such patients were studied using standard mucin and carbohydrate lectin staining methods. Sections from the tumour and adjacent and distant mucosa were stained to determine the pattern of histochemical changes. The abnormal staining patterns seen suggest that the adenocarcinomata arising at the enterovesical anastomosis are of intestinal origin. A hypothesis is advanced to explain the pathogenesis of these tumours.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Barresi G, Marafioti TM (1990) Mucin histochemistry and lectin binding sites in intestinal metaplasia of the urinary bladder. Histopathology 17:219
Edwards PD, Hurm RA, Jaeschke WE (1972) Conversion of cystitis glandularis to adenocarcinoma. J Urol 108:568
Filipe MI (1969) Value of histochemical reactions for mucosubstances in the diagnosis of certain pathological conditions of the colon and rectum. Gut 10:188
Filipe MI (1987) Gastrointestinal tract. In: Spicer SS (ed) Histochemistry in pathologic diagnosis, chapter 13. Dekker, New York, p 353
Grainger R, Kenny A, Walsh A (1988) Adenocarcinoma of the caecum occurring in a caecocystoplasty. Br J Urol 61:164
Hasegawa S, Oshima S, Kinukaw T et al. (1988) Adenocarcinoma of the bladder 29 years after ileocystoplasty. Br J Urol 61:162
Kadow C, Heaton ND, Paes T et al (1989) Adenocarcinoma in a substitution caecocystoplasty. Br J Surg 63:649
Leedham PW, England HR (1973) Adenocarcinoma developing in an ileocystoplasty. Br J Surg 60:158
Newbould M, McWilliam LJ (1990) A study of vesical adenocarcinoma, intestinal metaplasia and related lesions using mucin histochemistry. Histopathology 17:225
Nurse DE, Mundy AR (1989) Assessment of the malignant potential of cystoplasty. Br J Urol 64:489
Rosas-Uribe A, Luna MA (1969) Primary signet ring cell carcinoma of the urinary bladder. Arch Path 88:294
Silber SJ (1973) Carcinoma in the bladder left behind. J Urol 110:675
Smith P, Hardy GJ (1971) Carcinoma occurring as a late complication of ileocystoplasty. Br J Urol 43:576
Stewart M, Hill MH et al. (1981) The role of N-nitrosamine in carcinogenesis at the ureterocolic anastomosis. Br J Urol 53:115
Stewart M, Macrae FA et al (1982) Neoplasia and ureterosigmoidostomy: a colonoscopy survey. Br J Surg 69:414
Stone AR, Davies N, Stephenson TP (1987) Carcinoma associated with augmentation cystoplasty. Br J Urol 60:36
Strachan JR, Matthews J et al. (1987) Kinetic changes in experimental colonic urinary diversion. Br J Surg 74:1046
Traynor OJ, Wood CB, Costa N (1982) Ultrastructural alterations in the colonic mucus layer during carcinogenesis: a scanning electron microscope study. In: Chantler EN, Elder JB, Elstein M (eds) Mucus in health and disease-II. Plenum Press, New York, p 377
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Murray, K., Nurse, D.E. & Mundy, A.R. Malignant change in enterocystoplasty: a histochemical assessment. Urol. Res. 23, 21–25 (1995). https://doi.org/10.1007/BF00298846
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00298846