Abstract
The intravenous toxicity to the rat of 36 pyrethroids has been examined. With two exceptions they cause either (1) T-syndrome, consisting of aggressive sparring, sensitivity to external stimuli, fine progressing to gross whole body tremor and prostration or (2) CS-syndrome, consisting of pawing and burrowing behaviour, salivation, coarse tremor, progressing to sinuous writhing (choreoathetosis) and clonic seizures. The two exceptions presented a TS-syndrome with salivation associated with the T-syndrome. No clearcut relationship between chemical structure and symptoms of poisoning has emerged through some generalisations are discussed.
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Aldridge WN, Clothier B, Forshaw P, Johnson MK, Parker VH, Price RJ, Skilleter DN, Verschoyle RD, Stevens C (1978) The effect of DDT and pyrethroids cismethrin and decamethrin on the acetylcholine and cyclic nucleotide content of rat brain. Biochem. Pharmacol 27: 1703–1706
Barnes JM, Verschoyle RD (1974) Toxicity of new pyrethroid insecticide. Nature 248: (sn5450) 711
Carlton M (1977) Some effects of cismethrin on the rabbit nervous system. Pestic Sci 8: 700–712
Elliott M, Farnham AW, Janes NF, Needham PH, Pearson BC (1967) 5-Benzyl-3-furylmethyl chrysanthemate a new potent insecticide. Nature 213: (5075) 493–494
Elliott M, Farnham AW, Janes NF, Needham PH, Pulman DA, Stevenson JH (1973) A photostabile pyrethroid. Nature 246: (5429) 169–170
Elliott M, Farnham AW, Janes NF, Needham PH, Pulman DA (1974) Synthetic insecticide with a new order of activity. Nature 248: (5450) 710–711
Gray A, Connors TA (1980) Pestic Sci (in press)
Ray DE (1980) An EEG investigation of decamethrin-induced choreoathetosis in the rat. Exp Brain Res 38: 221–227
Ray DE, Cremer JE (1979) The action of decamethrin (a synthetic pyrethroid) on the rat. Pestic Biochem Physiol 10: 333–340
Sanderson DM (1959) A note on glycerol formal as a solvent in toxicity testing. J Pharm Pharmacol 11: 150–156
Verschoyle RD, Barnes JM (1972) Toxicity of natural and synthetic pyrethrins to rats. Pestic Biochem Physiol 2: 308–311
White INH, Verschoyle RD, Moradian MH, Barnes JM (1976) The relationship between brain levels of cismethrin and bioresmethrin in female rats and neurotoxic effects. Pestic Biochem Physiol 6: 491–500
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Verschoyle, R.D., Aldridge, W.N. Structure-activity relationships of some pyrethroids in rats. Arch. Toxicol. 45, 325–329 (1980). https://doi.org/10.1007/BF00293813
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DOI: https://doi.org/10.1007/BF00293813