Abstract
Isoniazid inactivation was studied in a sample of 100 subjects from Central Thailand. The frequency of the allele AcS (resulting in “slow” inactivation in the homozygous state) was calculated as 0.755. There is evidence for a simply additive dosage effect of the two genes AcR and AcS. The results are discussed with regard to other population studies and to recent findings concerning isoniazid inactivation and the activity of the involved enzymes in nonhuman primates.
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Schloot, W., Blume, K.G., Goedde, H.W. et al. Studies on isoniazid conversion in Thailand. Hum Genet 4, 274–279 (1967). https://doi.org/10.1007/BF00292200
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DOI: https://doi.org/10.1007/BF00292200